Publication Name	World Journal of Diabetes
Manuscript ID	117542
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Letter to the Editor
Article Title	Akkermansia muciniphila serves as an immunomodulator for type 1 diabetes mellitus: Promises and pitfalls
Manuscript Source	Invited Manuscript
All Author List	Ying Qian, Jun Xu, Jun-Min Wang, Xing-Li Wu and Yi-Yuan Zheng
Funding Agency and Grant Number
Corresponding Author	Yi-Yuan Zheng, Laboratory Center, Department of Gastroenterology, Shanghai Municipal Hospital of Traditional Chinese Medicine, No. 274 Zhijiang Middle Road, Shanghai 200071, China. iceroser@126.com
Key Words	Type 1 diabetes mellitus; Akkermansia muciniphila; Immunomodulator; Gut microbiota; Clinical application
Core Tip	This article offers a critical evaluation of the therapeutic potential of Akkermansia muciniphila in the context of type 1 diabetes mellitus. While the study has yielded promising results in terms of immunomodulatory effects, the absence of metabolic reversal highlights significant challenges in translating these findings into clinical applications. This article emphasizes the need for caution regarding the inhibition of immune pathways, interspecies variability, and potential ecological trade-offs within the gut microbiome. Future investigations should prioritize clinical trials and combination therapies to realize its therapeutic potential in type 1 diabetes mellitus.
Citation	Qian Y, Xu J, Wang JM, Wu XL, Zheng YY. Akkermansia muciniphila serves as an immunomodulator for type 1 diabetes mellitus: Promises and pitfalls. World J Diabetes 2026; In press

Received	2025-12-10 00:44
Peer-Review Started	2025-12-10 08:31
First Decision by Editorial Office Director	2026-01-06 06:35
Return for Revision	2026-01-06 06:35
Revised	2026-01-17 12:48
Publication Fee Transferred
Second Decision by Editor	2026-02-06 02:50
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-06 08:56
Articles in Press	2026-02-06 08:56
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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