Publication Name	World Journal of Gastroenterology
Manuscript ID	117544
Country	Egypt

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Helicobacter pylori eradication and the prevention of peptic ulcer bleeding and cardiovascular disease progression in chronic aspirin users
Manuscript Source	Invited Manuscript
All Author List	Atteyat A Semeya, Wael Ahmed Makled, Mohamed A Elnagdy, Rasha Elgamal and Amira A A Othman
Funding Agency and Grant Number
Corresponding Author	Amira A A Othman, Lecturer, MD, PhD, Principal Investigator, Department of Internal Medicine, Suez University, Cairo-Suez Road, Suez 43511, Suez, Egypt. amira.othman@med.suezuni.edu.eg
Key Words	Helicobacter pylori; Peptic ulcer bleeding; Low-dose aspirin; Eradication therapy; Gastroprotection
Core Tip	This prospective observational study shows that persistent Helicobacter pylori infection markedly increases the risk of peptic ulcer bleeding and cardiovascular (CV) disease progression in long-term low-dose aspirin users. Successful eradication lowered ulcer bleeding rates from 11.9% to 3.7% - an approximately 69% relative risk reduction- and was associated with significantly fewer CV events. These findings support routine Helicobacter pylori screening and eradication as a practical strategy to improve both gastrointestinal safety and CV outcomes in high-risk aspirin users.
Citation	Semeya AA, Makled WA, Elnagdy MA, Elgamal R, Othman AAA. Helicobacter pylori eradication and the prevention of peptic ulcer bleeding and cardiovascular disease progression in chronic aspirin users. World J Gastroenterol 2026; In press

Received	2025-12-10 00:40
Peer-Review Started	2025-12-10 00:40
First Decision by Editorial Office Director	2025-12-30 07:51
Return for Revision	2025-12-30 07:51
Revised	2026-01-01 01:58
Publication Fee Transferred
Second Decision by Editor	2026-02-12 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-12 23:38
Articles in Press	2026-02-12 23:38
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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