Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	117559
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Impact of target volume delineation accuracy on locoregional control and survival after postoperative radiotherapy for colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Yao Xing and Min Gu
Funding Agency and Grant Number
Corresponding Author	Yao Xing, Department of Radiation Oncology, Nantong First People’s Hospital (The Second Affiliated Hospital of Nantong University), No. 666 Shengli Road, Chongchuan District, Nantong 226000, Jiangsu Province, China. 18756991625@163.com
Key Words	Colorectal cancer; Postoperative radiotherapy; Target volume delineation; Survival prognosis; Recurrence pattern; Adverse events
Core Tip	Accurate target volume delineation is essential for effective postoperative radiotherapy in colorectal cancer. This study demonstrates that inaccurate target definition leads to markedly higher marginal and out-of-field recurrence, inferior disease-free and overall survival, and increased late intestinal toxicity. Target accuracy emerged as an independent prognostic factor comparable to nodal stage and margin status. These findings underscore the need for standardized delineation guidelines, multidisciplinary review, and advanced imaging integration to ensure optimal tumor coverage and minimize treatment failures.
Citation	Xing Y, Gu M. Impact of target volume delineation accuracy on locoregional control and survival after postoperative radiotherapy for colorectal cancer. World J Gastrointest Surg 2026; In press

Received	2026-01-16 09:39
Peer-Review Started	2026-01-16 09:39
First Decision by Editorial Office Director	2026-01-30 08:52
Return for Revision	2026-01-30 08:52
Revised	2026-02-08 10:44
Publication Fee Transferred	2026-02-18 08:52
Second Decision by Editor	2026-04-01 02:45
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-01 08:04
Articles in Press	2026-04-01 08:04
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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