Publication Name	World Journal of Diabetes
Manuscript ID	117583
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Observational Study
Article Title	Visceral fat area and remnant cholesterol in type 2 diabetes: Nonlinear associations and thresholds
Manuscript Source	Unsolicited Manuscript
All Author List	Dong-Jian Chai, Chun-Yan Zhu, Yi-Ming Zhang and Zi-Chen Rao
Funding Agency and Grant Number
Corresponding Author	Zi-Chen Rao, MD, Endocrinology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s Hospital, The Quzhou Affiliated Hospital of Wenzhou Medical University, No. 100 Minjiang Dadao, West District,, Quzhou 324000, Zhejiang Province, China. rzc1522@wmu.edu.cn
Key Words	Visceral fat area; Residual cholesterol; Residual cholesterol-inflammation index; Type 2 diabetes; Non-linear dose-response
Core Tip	This cross-sectional study of adults with type 2 diabetes (T2D) quantified visceral fat area (VFA) and examined its associations with residual cholesterol (RC) and the RC-inflammation index (RCII; RC/C-reactive protein). Higher VFA was independently associated with higher RC, and showed a clear non-linear pattern with a threshold at 126 cm2. RCII showed a weaker association and only a borderline threshold signal at 118 cm2, which should be interpreted as exploratory. These findings suggest that quantifying VFA may help contextualize remnant cholesterol-related burden beyond conventional lipid measures in T2D.
Citation	Chai DJ, Zhu CY, Zhang YM, Rao ZC. Visceral fat area and remnant cholesterol in type 2 diabetes: Nonlinear associations and thresholds. World J Diabetes 2026; In press

Received	2025-12-11 08:43
Peer-Review Started	2025-12-14 15:16
First Decision by Editorial Office Director	2026-01-09 08:02
Return for Revision	2026-01-09 08:02
Revised	2026-01-16 09:15
Publication Fee Transferred	2026-01-19 06:19
Second Decision by Editor	2026-03-03 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-10 06:04
Articles in Press	2026-03-10 06:04
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Typeset the Manuscript

ISSN	1948-9358 (online)
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