Publication Name	World Journal of Gastroenterology
Manuscript ID	117597
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Application of intraoperative laparoscopic ultrasound guidance combined with Sonazoid contrast in surgical treatment of colorectal liver metastasis
Manuscript Source	Unsolicited Manuscript
All Author List	Wen-Tao He, Hua Chen, Hong Li, Yu-Lin Li, Hao-Ran Wu, Wen-Bin Duan and Yang Liu
Funding Agency and Grant Number	Funding Agency Grant Number Major Scientific Research Project of National Clinical Key Specialty Z2023165
Corresponding Author	Yang Liu, MD, Department of General Surgery, Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde City), No.388, Ren MingRoad, Changde 415000, Hunan Province, China. 15873639390@163.com
Key Words	Colorectal cancer; Liver metastasis; Ultrasound guidance; Laparoscopy; Sonazoid contrast imaging
Core Tip	Advances in imaging technology have improved preoperative lesion localization and surgical planning by providing valuable visual references in the surgical treatment for liver metastases from colorectal cancer. However, strategies to better localize occult lesions intraoperatively following chemotherapy warrants further exploration. Sonazoid (Shizhuoan in Chinese) is a contrast agent taken up by Kupffer cells, which could facilitating further localization of hepatic lesions. However, reports on its intraoperative application in China remain limited. This study compared the visualization of target lesions during laparoscopic microwave ablation for colorectal liver metastases using Sonazoid-enhanced contrast-enhanced ultrasound vs gray-scale ultrasound.
Citation	He WT, Chen H, Li H, Li YL, Wu HR, Duan WB, Liu Y. Application of intraoperative laparoscopic ultrasound guidance combined with Sonazoid contrast in surgical treatment of colorectal liver metastasis. World J Gastroenterol 2026; In press

Received	2026-01-30 09:39
Peer-Review Started	2026-01-30 09:39
First Decision by Editorial Office Director	2026-02-12 07:35
Return for Revision	2026-02-12 07:35
Revised	2026-03-01 14:18
Publication Fee Transferred	2026-03-02 08:29
Second Decision by Editor	2026-03-16 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-17 09:12
Articles in Press	2026-03-17 09:12
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com