Publication Name	World Journal of Stem Cells
Manuscript ID	117622
Country	China

Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Combining mitochondrial antioxidant mitoquinone and mesenchymal stem cell therapy for amelioration of radiation-induced lung injury: Synergistic regenerative strategy
Manuscript Source	Unsolicited Manuscript
All Author List	Yan-Ling Hu, Zhong-Xiang Lin, Xiao-Yue Zhang, Guo-Li Li, Wei-Jie Liu, Zhong-Quan Shi, Xiao-Han Li and Zhen-Zhou Yang
Funding Agency and Grant Number
Corresponding Author	Zhen-Zhou Yang, Department of Cancer Center, The Second Affiliated Hospital of Chongqing Medical University, No. 74 Linjiang Road, Chongqing 400000, China. yangzz@cqmu.edu.cn
Key Words	Radiation-induced lung injury; Mitoquinone; Mesenchymal stem cells; Mitochondrial oxidative stress; Synergistic therapy
Core Tip	Radiation-induced lung injury (RILI) remains a major limitation in thoracic radiotherapy, driven by oxidative stress, mitochondrial dysfunction, and inflammation-fibrosis progression. Mesenchymal stem cells offer therapeutic potential but have limited survival in oxidative environments. This study demonstrates that combining the mitochondria-targeted antioxidant mitoquinone with mesenchymal stem cells significantly enhances treatment efficacy in a murine RILI model. The combination therapy improved lung function, reduced oxidative stress, restored mitochondrial homeostasis, and attenuated inflammation and fibrosis more effectively than either monotherapy. These findings highlight a dual-target strategy that optimizes stem cell-based interventions, offering a promising approach for RILI management.
Citation	Hu YL, Lin ZX, Zhang XY, Li GL, Liu WJ, Shi ZQ, Li XH, Yang ZZ. Combining mitochondrial antioxidant mitoquinone and mesenchymal stem cell therapy for amelioration of radiation-induced lung injury: Synergistic regenerative strategy. World J Stem Cells 2026; In press

Received	2026-01-20 10:00
Peer-Review Started	2026-01-20 10:00
First Decision by Editorial Office Director	2026-01-29 08:32
Return for Revision	2026-01-29 08:32
Revised	2026-02-07 09:46
Publication Fee Transferred	2026-02-12 13:26
Second Decision by Editor	2026-03-23 02:52
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-30 13:11
Articles in Press	2026-03-30 13:11
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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