Publication Name	World Journal of Gastroenterology
Manuscript ID	117657
DOI	10.3748/wjg.117657
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Human umbilical cord mesenchymal stem cell-derived exosomes alleviate the experimental colitis by maintaining intestinal barrier and remodeling macrophage polarization
Manuscript Source	Unsolicited Manuscript
All Author List	Lian-Lian Tian, Jun Zhu, Zhen-Zhen Fan, Yan-Ting Shi, Liu-Qing Zhao, Jin-Dan He and Jie Liang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82370588 National Natural Science Foundation of China No. 82570614 National Natural Science Foundation of China No. 92259302 The Innovative Medical Research Boosting Project No. XJZT25CX41 Special Project for Clinical New Technologies of Xijing Hospital No. 2024XJSY17
Corresponding Author	Jie Liang, MD, PhD, Professor, Xijing Hospital of Digestive Diseases, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, No. 127 Changle West Road, Xincheng District, Xi’an 710032, Shaanxi Province, China. liangjie@fmmu.edu.cn
Key Words	Inflammatory bowel disease; Human umbilical cord mesenchymal stem cells derived-exosomes; Intestinal barrier; Macrophage phenotypic transformation; Janus kinase/signal transducer and activator of transcription signaling
Core Tip	In this study, we found that human umbilical cord mesenchymal stem cell-derived exosome (hucMSC-Ex) ameliorated dextran sulfate sodium-induced colitis by reducing colonic inflammation and maintaining intestinal mucosa permeability, while promoting the transformation of immature pro-inflammatory macrophages into mature anti-inflammatory macrophages. In vitro, hucMSC-Ex also modulated the phenotypic changes in RAW264.7 cells. Furthermore, hucMSC-Ex altered the phenotypic transformation of macrophages, thereby ameliorating experimental colitis through modulation of the Janus kinase/signal transducer and activator of transcription signaling pathway in vivo and in vitro. This study not only provides guidance for further research on molecular mechanisms of inflammatory bowel disease (IBD), but also offers a theoretical basis for targeted therapy of IBD.
Citation	Tian LL, Zhu J, Fan ZZ, Shi YT, Zhao LQ, He JD, Liang J. Human umbilical cord mesenchymal stem cell-derived exosomes alleviate the experimental colitis by maintaining intestinal barrier and remodeling macrophage polarization. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.117657
PDF	117657-in-press.pdf

Received	2025-12-22 07:43
Peer-Review Started	2025-12-22 07:43
First Decision by Editorial Office Director	2026-01-28 09:22
Return for Revision	2026-01-28 09:22
Revised	2026-03-05 22:43
Publication Fee Transferred	2026-03-09 07:09
Second Decision by Editor	2026-09-02 02:53
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-04 09:02
Articles in Press	2026-09-04 09:02
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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