Publication Name	World Journal of Nephrology
Manuscript ID	117674
Country	India

Category	Transplantation
Manuscript Type	Letter to the Editor
Article Title	Post-transplant diabetes mellitus prevention in renal transplantation: Are we missing vitamin D?
Manuscript Source	Invited Manuscript
All Author List	Adarsh kumar and Himansu Sekhar Mahapatra
Funding Agency and Grant Number
Corresponding Author	Adarsh kumar, Associate Professor, DM, MD, Department of Nephrology and Renal Transplant Medicine, Vardhman Mahavir Medical College and Safdarjung Hospital, Ansari Nagar East, Near AIIMS Metro Station, New Delhi 110029, India. adarshnephro081@gmail.com
Key Words	Post-transplant diabetes mellitus; Vitamin D deficiency; Renal Transplantation; Calcineurin inhibitors; Glucocorticoids
Core Tip	Vitamin D deficiency is nearly universal among kidney transplant recipients (RTRs) but remains underappreciated as a contributor to post-transplant diabetes mellitus (PTDM). Recent evidence shows that low pre- and early post-transplant vitamin D levels independently increase PTDM risk. Integrating vitamin D optimization into transplant care may offer a simple strategy to prevent PTDM and improve long-term graft outcomes. Doses of vitamin D necessary to achieve a serum 25-hydroxyvitamin D concentration of ≥ 30 ng/mL in RTRs are much higher than those recommended in the general population. Vitamin D repletion is a safe, inexpensive, and widely accessible intervention that may enhance insulin secretion, improve insulin sensitivity, and attenuate the metabolic toxicity associated with calcineurin inhibitors and glucocorticoids. Further well-designed prospective studies are needed to elucidate underlying mechanisms and evaluate the impact of vitamin D supplementation on PTDM.
Citation	Kumar A, Mahapatra HS. Post-transplant diabetes mellitus prevention in renal transplantation: Are we missing vitamin D? World J Nephrol 2026; In press

Received	2025-12-15 01:47
Peer-Review Started	2025-12-15 01:47
First Decision by Editorial Office Director	2026-01-09 08:58
Return for Revision	2026-01-09 08:58
Revised	2026-01-22 09:48
Publication Fee Transferred
Second Decision by Editor	2026-02-13 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-13 08:22
Articles in Press	2026-02-13 08:22
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6124 (online)
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