Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	117693
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Randomized Controlled Trial
Article Title	Crohn’s disease-related perianal fistula: A clinic research
Manuscript Source	Unsolicited Manuscript
All Author List	Wei-Feng Zhang, Wen-Ting Fan, Wei-Wei Gao, Zheng Wu, Ran-Ran Liu and Cheng-Wei Ruan
Funding Agency and Grant Number	Funding Agency Grant Number Construction Project of High Level Hospital of Jiangsu Province GSPJS202508
Corresponding Author	Cheng-Wei Ruan, Researcher, Department of Colorectal Surgery, The Affiliated Hospital of Xuzhou Medical University, No. 99 Huaihai West Road, Xuzhou 221004, Jiangsu Province, China. ruancw666@126.com
Key Words	Loose seton; Mahuang Shengma Decoction; Crohn’s disease-related perianal fistula; External application; Clinical study
Core Tip	This study is the first to evaluate the efficacy of the comprehensive regimen of seton drainage combined with oral and external Traditional Chinese medicine (TCM) for the treatment of simple Crohn’s disease-related perianal fistula. The results demonstrate that this regimen can significantly shorten wound healing time, improve TCM syndromes and perianal symptoms, and has a favorable safety profile, thereby providing a novel integrated TCM and Western medicine therapeutic strategy for clinical practice.
Citation	Zhang WF, Fan WT, Gao WW, Wu Z, Liu RR, Ruan CW. Crohn’s disease-related perianal fistula: A clinic research. World J Gastrointest Surg 2026; In press

Received	2025-12-26 10:02
Peer-Review Started	2025-12-26 10:03
First Decision by Editorial Office Director	2026-01-09 07:38
Return for Revision	2026-01-09 07:38
Revised	2026-01-19 17:15
Publication Fee Transferred	2026-01-20 03:29
Second Decision by Editor	2026-02-03 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-03 07:59
Articles in Press	2026-02-03 07:59
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com