Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	117694
Country	China

Category	Radiology, Nuclear Medicine & Medical Imaging
Manuscript Type	Retrospective Study
Article Title	Tumor-related imaging parameters predict response and survival after neoadjuvant chemoradiotherapy in rectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Ting-ting Nie, Yu-Xia Li, Xuan Yang, Tao Liu, Xiao-Hui Niu, Xiao-Fang Guo and Yu-Lin Liu
Funding Agency and Grant Number	Funding Agency Grant Number Guiding Program of Natural Science Foundation of Hubei Province No. 2024AFC050 Special Project of Biomedical Research Center of Hubei Cancer Hospital No. 2022SWZX06 Hubei Province “Chutian Talents Program” Medical and Health Personnel Project No. CTYC001
Corresponding Author	Xiao-Fang Guo, MD, PhD, Department of Radiology, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 116 Zhuodaoquan South Road, Hongshan District, Wuhan 430079, Hubei Province, China. guoxiaofang2001@163.com
Key Words	Sarcopenia; Rectal cancer; Neoadjuvant therapy; Response; Overall survival
Core Tip	This study evaluated the impact of pretreatment sarcopenia and tumor-related magnetic resonance imaging parameters on the response to neoadjuvant chemoradiotherapy and overall survival in rectal cancer patients. The results show that while sarcopenia was not an independent predictor of treatment response or survival, tumor-related factors such as tumor length, mesorectal fascia involvement, and clinical T/N stage were significant predictors. These findings highlight the value of tumor-related imaging parameters in pretreatment risk stratification and personalized management for rectal cancer patients undergoing neoadjuvant chemoradiotherapy.
Citation	Nie TT, Li YX, Yang X, Liu T, Niu XH, Guo XF, Liu YL. Tumor-related imaging parameters predict response and survival after neoadjuvant chemoradiotherapy in rectal cancer. World J Gastrointest Oncol 2026; In press

Received	2025-12-15 03:59
Peer-Review Started	2025-12-15 03:59
First Decision by Editorial Office Director	2025-12-24 09:40
Return for Revision	2025-12-24 09:40
Revised	2026-01-06 01:57
Publication Fee Transferred	2026-01-08 12:11
Second Decision by Editor	2026-02-05 02:47
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-05 07:37
Articles in Press	2026-02-05 07:37
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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