Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	117697
Country	China

Category	Nanoscience & Nanotechnology
Manuscript Type	Basic Study
Article Title	Low-pH preconditioned macrophage-derived extracellular vesicles enable targeted and enhanced paclitaxel therapy in gastric cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Jing-Hui Wang, Ming-Li Hu, Min Shi, Jia-Li Ma, Jing Yang and Yu-Gang Wang
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of the Science and Technology Commission of Shanghai Municipality 23ZR1458300 Key Discipline Project of Shanghai Municipal Health System 2024ZDXK0004 Special project for Clinical Research in Health Industry of Shanghai Municipal Health Commission 20254Y0097 Youth Project Fund of Changning District Health Commission 2024QN02 Research Fund of Key Laboratory for Translational Research and Innovative Therapeutics of Gastrointestinal Oncology ZDSYS-2023-04
Corresponding Author	Yu-Gang Wang, Professor, Department of Gastroenterology, Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine, No. 1111 Xianxia Road, Changning District, Shanghai 200336, China. wyg0061@shtrhospital.com
Key Words	Extracellular vesicles; Low-pH preconditioning; Targeted delivery; Combined therapy; Gastric cancer
Core Tip	In this study, we report a microenvironment-inspired strategy to customize macrophage-derived extracellular vesicles (EVs) through low-pH preconditioning, mimicking the acidic characteristics of the tumor microenvironment. This approach markedly enhances EVs' tumor targeting and endows them with a distinct miRNA cargo associated with reported anti-tumor functions. When used as nanocarriers for paclitaxel (PTX), the resulting biomimetic system (PTX@LP-EV) achieves superior anti-tumor efficacy in gastric cancer models. Mechanistically, EV-borne miRNAs induced by tumor microenvironmental stimulation may cooperatively suppress pro-tumorigenic genes, which is consistent with the observed enhanced therapeutic effects.
Citation	Wang JH, Hu ML, Shi M, Ma JL, Yang J, Wang YG. Low-pH preconditioned macrophage-derived extracellular vesicles enable targeted and enhanced paclitaxel therapy in gastric cancer. World J Gastrointest Oncol 2026; In press

Received	2025-12-24 05:42
Peer-Review Started	2025-12-24 05:43
First Decision by Editorial Office Director	2026-01-07 10:25
Return for Revision	2026-01-07 13:50
Revised	2026-01-21 13:44
Publication Fee Transferred
Second Decision by Editor	2026-02-25 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-25 04:41
Articles in Press	2026-02-25 04:41
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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