Publication Name	World Journal of Clinical Oncology
Manuscript ID	117705
Country	China

Category	Oncology
Manuscript Type	Review
Article Title	Breast cancer and metabolic comorbidities: From epidemiology and molecular mechanisms to precision interventions
Manuscript Source	Unsolicited Manuscript
All Author List	Shen-Hao Zhang, Yang Yang and Yuan Zhang
Funding Agency and Grant Number
Corresponding Author	Yuan Zhang, PhD, Medical College, Yanbian University, No. 977 Gongyuan Road, Yanji 133002, Jilin Province, China. 0000008641@ybu.edu.cn
Key Words	Breast cancer; Metabolic comorbidities; Obesity; Type 2 diabetes mellitus; Precision interventions
Core Tip	Reframes metabolic comorbidities as active, modifiable drivers of breast cancer. Integrates epidemiology, tumour microenvironment, signalling and gut microbiota. Maps obesity, type 2 diabetes mellitus and metabolic syndrome pathways to pharmacologic and lifestyle interventions. Highlights glucagon-like peptide-1 receptor agonists, sodium-glucose cotransporter 2 inhibitors and bariatric surgery as precision tools. Proposes a metabolic oncology model with artificial intelligence-enabled multimodal risk prediction.
Citation	Zhang SH, Yang Y, Zhang Y. Breast cancer and metabolic comorbidities: From epidemiology and molecular mechanisms to precision interventions. World J Clin Oncol 2026; In press

Received	2025-12-15 03:44
Peer-Review Started	2025-12-15 03:44
First Decision by Editorial Office Director	2025-12-25 08:21
Return for Revision	2025-12-25 08:21
Revised	2026-01-05 06:30
Publication Fee Transferred	2026-01-09 10:22
Second Decision by Editor	2026-02-11 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-11 07:01
Articles in Press	2026-02-11 07:01
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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