Publication Name	World Journal of Hepatology
Manuscript ID	117720
Country	Egypt

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	From algorithm to bedside: Navigating the promise and perils of implementing machine learning for variceal bleeding mortality prediction
Manuscript Source	Invited Manuscript
All Author List	Amira A A Othman
Funding Agency and Grant Number
Corresponding Author	Amira A A Othman, Lecturer, MD, PhD, Principal Investigator, Department of Internal Medicine, Suez University, Cairo-Suez Road, Suez 43511, Egypt. amira.othman@med.suezuni.edu.eg
Key Words	Artificial intelligence; Clinical decision support systems; Implementation science; Health equity; Prognostication; Cirrhosis complications
Core Tip	Machine learning is transitioning from theoretical promise to practical implementation within hepatology, particularly in high-risk conditions such as acute esophageal variceal bleeding. The study by Rech et al distinguishes itself by combining high-performing mortality prediction with prospective validation and real-world deployment as an online calculator. This editorial highlights why such efforts represent an important step toward bridging the persistent gap between algorithm development and clinical adoption. Yet we also explore the remaining challenges-model interpretability, ethical complexities surrounding race-based predictors, workflow integration, model drift, and the need for multicenter external validation. Understanding these dimensions is crucial for translating artificial intelligence into safer, more equitable, and genuinely impactful tools at the bedside.
Citation	Othman AAA. From algorithm to bedside: Navigating the promise and perils of implementing machine learning for variceal bleeding mortality prediction. World J Hepatol 2026; In press

Received	2025-12-15 03:11
Peer-Review Started	2025-12-15 03:11
First Decision by Editorial Office Director	2026-02-14 07:31
Return for Revision	2026-02-14 07:31
Revised	2026-02-16 23:38
Publication Fee Transferred
Second Decision by Editor	2026-03-25 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-25 12:31
Articles in Press	2026-03-25 12:31
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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