Publication Name	World Journal of Diabetes
Manuscript ID	117752
Country	Viet Nam

Category	Endocrinology & Metabolism
Manuscript Type	Editorial
Article Title	Revisiting the pancreas-liver axis in diabetes: The emerging role of exosomal miR-375-3p
Manuscript Source	Invited Manuscript
All Author List	Bich Ngoc Hoang Thi, Thang Viet Luong, Hai Nguyen Ngoc Dang, Hau Phuc Tran and Trung Tran Nguyen
Funding Agency and Grant Number
Corresponding Author	Trung Tran Nguyen, Lecturer, PhD, Researcher, Nguyen Tat Thanh Hi-Tech Institute, Nguyen Tat Thanh University, 300A Nguyen Tat Thanh, Ho Chi Minh City 700000, Viet Nam. nguyen.trung@ntt.edu.vn
Key Words	Type 2 diabetes mellitus; Beta-cell glucotoxicity; Exosomal miRNA; Hepatic insulin resistance; Pancreatic-liver communication
Core Tip	Type 2 diabetes mellitus is characterized by progressive β-cell dysfunction and hepatic insulin resistance, yet the molecular signals linking pancreatic stress to impaired liver glucose metabolism remain incompletely defined. Recent evidence has revealed that exosomal miR-375-3p is a novel mediator of pancreas-liver communication, whereby glucotoxic β cells transfer regulatory miRNA cargo to hepatocytes to repress protein for immunoglobulin kappa J region, disrupt protein kinase B/glycogen synthase kinase signaling, and reduce hepatic glycogen storage. This editorial highlights the conceptual importance of this exosome-miRNAs axis, critically evaluates its current limitations, and discusses its potential implications for understanding disease progression, biomarker development, and therapeutic targeting in type 2 diabetes.
Citation	Hoang Thi BN, Luong TV, Dang HNN, Tran HP, Nguyen TT. Revisiting the pancreas-liver axis in diabetes: The emerging role of exosomal miR-375-3p. World J Diabetes 2026; In press

Received	2025-12-16 02:36
Peer-Review Started	2025-12-16 09:54
First Decision by Editorial Office Director	2025-12-31 07:55
Return for Revision	2025-12-31 07:55
Revised	2026-01-19 10:17
Publication Fee Transferred
Second Decision by Editor	2026-02-03 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-03 06:48
Articles in Press	2026-02-03 06:48
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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