Publication Name	World Journal of Gastroenterology
Manuscript ID	117754
DOI	10.3748/wjg.117754
Country	Spain

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Ongoing need for biomarkers predicting activity of inflammatory bowel disease
Manuscript Source	Invited Manuscript
All Author List	M Jesús Fernández-Aceñero
Funding Agency and Grant Number
Corresponding Author	M Jesús Fernández-Aceñero, Full Professor, Department of Surgical Pathology, Health Research Institute of the Hospital Clínico San Carlos, Hospital Clínico San Carlos, Professor Martín Lagos Street, Madrid 28040, Spain. mgg10167@gmail.com
Key Words	Inflammatory bowel disease; Crohn’s disease; Ulcerative colitis; Biomarkers; Relapse; Calprotectin; Oncostatin M; Micro-RNA; Artificial intelligence; Therapeutic drug monitoring
Core Tip	Inflammatory bowel disease is a severe relapsing inflammatory disease and early detection and treatment can help improve patients’ outcome. Although endoscopic and histopathological scores remain as the most reliable marker for disease relapses, they are invasive and there is a clear need to find biomarkers that allow a non-invasive and practical approach to disease diagnosis and treatment. Fecal calprotectin has emerged as the most useful biomarker, but there is still a great need to increase accuracy. Novel technologies, including the different omics, and several emerging biomarkers promise to improve the field of inflammatory bowel disease diagnosis and management in the near future, also fueled by the development of artificial intelligence-based strategies.
Citation	Fernández-Aceñero MJ. Ongoing need for biomarkers predicting activity of inflammatory bowel disease. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.117754
PDF	117754-in-press.pdf

Received	2025-12-15 05:09
Peer-Review Started	2025-12-15 05:09
First Decision by Editorial Office Director	2026-01-28 09:21
Return for Revision	2026-01-28 09:21
Revised	2026-06-24 08:47
Publication Fee Transferred
Second Decision by Editor	2026-07-13 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-13 08:07
Articles in Press	2026-07-13 08:07
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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