Publication Name	World Journal of Hepatology
Manuscript ID	117761
Country	Spain

Category	Oncology
Manuscript Type	Editorial
Article Title	Is stereotactic body radiation therapy feasible in hepatocellular carcinoma with portal vein tumor thrombosis?
Manuscript Source	Invited Manuscript
All Author List	Tomás González and Abrahams Ocanto
Funding Agency and Grant Number
Corresponding Author	Abrahams Ocanto, MD, Department of Radiation Oncology, San Francisco de Asís University Hospital, Genesis Care, Calle Joaquín Costa 28, Madrid 28002, Spain. abraham.ocanto@gmail.com
Key Words	Hepatocellular carcinoma; Portal venous tumor thrombosis; Stereotactic body radiation therapy; Radiotherapy; Liver cancer
Core Tip	Portal vein tumor thrombosis is a common and challenging presentation in hepatocellular carcinoma, significantly limiting treatment options. This retrospective study highlights the safety and efficacy of stereotactic body radiation therapy as a locoregional treatment in patients with unresectable hepatocellular carcinoma and portal vein tumor thrombosis. With an encouraging response rate of 83.3% and a median overall survival of 13 months, stereotactic body radiation therapy demonstrates promising early outcomes and minimal toxicity, supporting its role as a viable therapeutic option in this difficult-to-treat population.
Citation	González T, Ocanto A. Is stereotactic body radiation therapy feasible in hepatocellular carcinoma with portal vein tumor thrombosis? World J Hepatol 2026; In press

Received	2025-12-15 05:00
Peer-Review Started	2025-12-15 05:01
First Decision by Editorial Office Director	2025-12-24 10:14
Return for Revision	2025-12-24 10:14
Revised	2025-12-30 12:26
Publication Fee Transferred
Second Decision by Editor	2026-02-04 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-04 13:27
Articles in Press	2026-02-04 13:27
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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