Publication Name	World Journal of Cardiology
Manuscript ID	117770
Country	China

Category	Cell Biology
Manuscript Type	Letter to the Editor
Article Title	Interpreting the protective role of exogenous nicotinamide adenine dinucleotide in myocardial ischemia/reperfusion injury: Insights into the ROS-NLRP3-pyroptosis axis
Manuscript Source	Invited Manuscript
All Author List	Li Jia, Zi-Wei Wang and Guo-Hua Gong
Funding Agency and Grant Number
Corresponding Author	Guo-Hua Gong, Full Professor, Professor, Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, No. 82 West College Road, Wenzhou 325035, Zhejiang Province, China. guohgong@wmu.edu.cn
Key Words	Nicotinamide adenine dinucleotide; Hypoxia/reoxygenation; Reactive oxygen species; H9c2; Oxidative stress
Core Tip	This commentary highlights recent evidence suggesting that exogenous nicotinamide adenine dinucleotide (NAD⁺) protects against myocardial ischemia/reperfusion injury by interrupting the reactive oxygen species-NLR family pyrin domain containing 3-pyroptosis axis. In addition to simply replenishing metabolic substrates, NAD⁺ acts as a “metabolic-immune” dual regulator, effectively suppressing inflammatory cascades and preventing gasdermin D-mediated cell death. These insights position NAD⁺ not only as an antiaging supplement but also as a promising, broad-spectrum therapeutic strategy for preserving myocardial viability in acute cardiac events.
Citation	Jia L, Wang ZW, Gong GH. Interpreting the protective role of exogenous nicotinamide adenine dinucleotide in myocardial ischemia/reperfusion injury: Insights into the ROS-NLRP3-pyroptosis axis. World J Cardiol 2026; In press

Received	2025-12-16 01:38
Peer-Review Started	2025-12-16 01:39
First Decision by Editorial Office Director	2025-12-25 08:17
Return for Revision	2025-12-25 08:17
Revised	2026-01-05 07:16
Publication Fee Transferred
Second Decision by Editor	2026-02-13 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-13 03:24
Articles in Press	2026-02-13 03:24
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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