Publication Name	World Journal of Hepatology
Manuscript ID	117794
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Ziziphus spina-christi leaf extract in schistosomal liver disease: Biomarker gains in hepatectomy model-perioperatively actionable?
Manuscript Source	Invited Manuscript
All Author List	Xue-Hu Song, Hao-Xian Gou, Zhu Huang and Zhu-Lin Luo
Funding Agency and Grant Number
Corresponding Author	Zhu-Lin Luo, Professor, Department of General Surgery, The General Hospital of Western Theater Command, 270 Rongdu Road, Jinniu District, Chengdu 610083, Sichuan Province, China. lzl810130@163.com
Key Words	Schistosomiasis; Liver fibrosis; Hepatobiliary surgery; Ziziphus spina-christi leaf extract; Perioperative risk
Core Tip	This editorial examines a hamster model of Schistosoma mansoni-induced fibrosis, in which Ziziphus spina-christi leaf extract reduced egg burden and improved inflammatory markers. Although these preclinical findings are insufficient to establish clinical significance, they highlight key areas for future research, including standardizing interventions, conducting comprehensive safety profiling, and adopting rigorous study designs.
Citation	Song XH, Gou HX, Huang Z, Luo ZL. Ziziphus spina-christi leaf extract in schistosomal liver disease: Biomarker gains in hepatectomy model-perioperatively actionable? World J Hepatol 2026; In press

Received	2025-12-16 00:51
Peer-Review Started	2025-12-16 00:52
First Decision by Editorial Office Director	2026-01-09 08:57
Return for Revision	2026-01-09 08:57
Revised	2026-01-30 06:32
Publication Fee Transferred
Second Decision by Editor	2026-02-25 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-25 08:15
Articles in Press	2026-02-25 08:15
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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