Publication Name	World Journal of Gastroenterology
Manuscript ID	117819
Country	China

Category	Research & Experimental Medicine
Manuscript Type	Basic Study
Article Title	Emodin ameliorates cholestatic liver injury by regulating bile acid metabolism and gut microbiota in mice
Manuscript Source	Unsolicited Manuscript
All Author List	Chen-Xi Wang, Li-Ming Wang, Zhi-Fei Fu, Xin Zhao, Li-Feng Han and Yue-Fen Lou
Funding Agency and Grant Number	Funding Agency Grant Number Shanghai Hongkou District Health and Wellness Committee Medical Research Project Hongwei 2403-07 Shanghai Hongkou District Health and Wellness Committee Traditional Chinese Medicine Research Project HKZYY-2025-35 Shanghai Fourth People’s Hospital Research Launch Special Project sykyqd09701 Shanghai Fourth People’s Hospital Discipline Promotion Project SY-XKZT-2024-1013 Shanghai 2023 “Science and Technology Innovation Action Plan” Biomedical Technology Support Special Project 23S21900900 National Natural Science Foundation of China 82274362
Corresponding Author	Yue-Fen Lou, Chief Pharmacist, Department of Pharmacy, Shanghai Fourth People’s Hospital Affiliated to Tongji University School of Medicine, No. 1279 Sanmen Road, Hongkou District, Shanghai 200434, China. louyuefen@tongji.edu.cn
Key Words	Emodin; Cholestatic liver injury; Metabolomics; Bile acid metabolism; Gut microbiota
Core Tip	Our study revealed the beneficial effects of emodin (Emo) in alleviating cholestatic liver injury (CLI). Bile acid metabolism was altered during CLI, which was normalized by Emo. Emo altered gut microbiota composition. Fecal microbiota transplantation confirmed the microbiota-dependent anti-CLI efficacy of Emo and its therapeutic effect on the gut microbiota, especially Escherichia-Shigella. These findings will provide new insights into exploring the anti-CLI mechanism of Emo and its potential treatment strategies for CLI.
Citation	Wang CX, Wang LM, Fu ZF, Zhao X, Han LF, Lou YF. Emodin ameliorates cholestatic liver injury by regulating bile acid metabolism and gut microbiota in mice. World J Gastroenterol 2026; In press

Received	2025-12-23 10:07
Peer-Review Started	2025-12-23 10:07
First Decision by Editorial Office Director	2026-01-20 09:43
Return for Revision	2026-01-20 09:43
Revised	2026-01-29 02:05
Publication Fee Transferred	2026-02-13 08:29
Second Decision by Editor	2026-04-08 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-08 08:43
Articles in Press	2026-04-08 08:43
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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