Publication Name	World Journal of Cardiology
Manuscript ID	117821
Country	China

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Basic Study
Article Title	Landiolol modulates sodium 1.5 ion and connexin-43 to reduce sepsis ventricular arrhythmias
Manuscript Source	Unsolicited Manuscript
All Author List	Peng-Fei Hu, Ling-Yu Bai, Ming Zhao, Kui-Ying Ma, Li-Ying Xuan and Xin Qi
Funding Agency and Grant Number	Funding Agency Grant Number Inner Mongolia Natural Science Foundation Project of China No. 2020MS08031 Inner Mongolia Natural Science Foundation Project of China No. 2021MS08069 Inner Mongolia Natural Science Foundation Project of China No. 2023LHMS08082 Education Institutions in Inner Mongolia Autonomous Region of China No. NJZY22456
Corresponding Author	Xin Qi, Chief Physician, Department of Cardiology, Tianjin Union Medicine Center, The First Affiliated Hospital of Nankai University, No. 190 Jieyuan Road, Hongqiao District, Tianjin 300121, China. qixinx2011@126.com
Key Words	Sodium 1.5 ion channel; Connexin-43; Ventricular arrhythmia; Sepsis; Landiolol
Core Tip	Landiolol, a beta-blocker, can treat ventricular arrhythmias caused by sepsis. In this study, a rat sepsis model was first established, and the animals then received landiolol. Cardiac electrophysiological experiments and ultrastructural observations of the myocardium were conducted to clarify the electrophysiological effects and mechanisms of landiolol on ventricular myocytes in septic rats. It showed that landiolol could reduce the occurrence of ventricular arrhythmias in sepsis rats through inhibiting inflammatory cells, reducing myocardial fibrosis, reversing ventricular remodeling, and decreasing the expression of connexin-43 and sodium 1.5 ion.
Citation	Hu PF, Bai LY, Zhao M, Ma KY, Xuan LY, Qi X. Landiolol modulates sodium 1.5 ion and connexin-43 to reduce sepsis ventricular arrhythmias. World J Cardiol 2026; In press

Received	2025-12-17 02:36
Peer-Review Started	2025-12-17 02:36
First Decision by Editorial Office Director	2025-12-31 07:57
Return for Revision	2025-12-31 07:57
Revised	2026-01-04 03:46
Publication Fee Transferred	2026-01-06 05:25
Second Decision by Editor	2026-02-09 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-09 05:38
Articles in Press	2026-02-09 05:38
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ISSN	1949-8462 (online)
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