Publication Name	World Journal of Gastroenterology
Manuscript ID	117823
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Clinical significance of autoantibody profiling and systemic inflammation in predicting outcomes of gastric cancer patients undergoing immunotherapy
Manuscript Source	Unsolicited Manuscript
All Author List	Pei-Ming Zheng, Li-Bo Ouyang, Rong Wang, Ke-Ying Jing, Hui-Jie Gao and Chun-Kai Zhu
Funding Agency and Grant Number	Funding Agency Grant Number Henan Provincial Program for Young and Middle-Aged Innovators in Health Science and Technology No. LJRC2024002 Natural Science Foundation of Henan Province No. 252300421373
Corresponding Author	Pei-Ming Zheng, Associate Chief Physician, Department of Clinical Laboratory, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, No. 7 Weiwu Road, Jinshui District, Zhengzhou 450003, Henan Province, China. peimingz@sina.com
Key Words	Gastric cancer; Immunotherapy; Antinuclear antibody; Extractable nuclear antigen; Prognostic model; Systemic inflammation
Core Tip	Antinuclear antibody (ANA), extractable nuclear antigen (ENA) and systemic inflammation have been implicated in cancer prognosis, their combined role predicting outcomes of gastric cancer patients undergoing immunotherapy. This study confirmed autoantibody, particularly ANA/ENA, along with other indicators serves as independent factors for prognosis in gastric cancer patients undergoing immunotherapy. The assessment of autoantibody profiles provides a novel perspective for optimizing risk stratification and treatment methods.
Citation	Zheng PM, Ouyang LB, Wang R, Jing KY, Gao HJ, Zhu CK. Clinical significance of autoantibody profiling and systemic inflammation in predicting outcomes of gastric cancer patients undergoing immunotherapy. World J Gastroenterol 2026; In press

Received	2025-12-18 02:45
Peer-Review Started	2025-12-18 02:45
First Decision by Editorial Office Director	2026-01-08 09:27
Return for Revision	2026-01-08 09:27
Revised	2026-01-13 08:16
Publication Fee Transferred	2026-01-15 07:41
Second Decision by Editor	2026-02-04 02:52
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-04 08:17
Articles in Press	2026-02-04 08:17
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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