Publication Name	World Journal of Psychiatry
Manuscript ID	117824
Country	China

Category	Psychiatry
Manuscript Type	Observational Study
Article Title	Tardive dyskinesia-depression association in Chinese patients with chronic schizophrenia: The mediating role of insomnia and gender differences
Manuscript Source	Unsolicited Manuscript
All Author List	San-Rong Xiao, Qiu-Yue Yin, Jing-Min Zhu, Yan Liu, Wen-Zhi Tan, Ting Wang and Xiang-Yang Zhang
Funding Agency and Grant Number
Corresponding Author	Xiang-Yang Zhang, Associate Research Scientist, PhD, Postdoc, Professor, Research Fellow, Institute of Psychology, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing,China., No. 16 Lincui Road, Chaoyang District, Beijing 100101, China. zhangxy@psych.ac.cn
Key Words	Tardive dyskinesia; Depression; Chronic schizophrenia; Insomnia; Mediation effect; Gender differences
Core Tip	This study of 669 Chinese patients with chronic schizophrenia demonstrates that tardive dyskinesia (TD) is associated with increased depressive severity, with insomnia partially mediating this relationship (accounting for 38% of the total effect). Gender differences were identified: Female patients with TD exhibited more severe overall depression, greater diurnal variation, and increased psychomotor retardation, whereas male patients with TD differed from non-TD males only in diurnal variation. These findings point to the critical need for systematic evaluation of insomnia and depression in the TD patient population and highlight the need for gender-specific interventions to optimize care in this vulnerable population.
Citation	Xiao SR, Yin QY, Zhu JM, Liu Y, Tan WZ, Wang T, Zhang XY. Tardive dyskinesia-depression association in Chinese patients with chronic schizophrenia: The mediating role of insomnia and gender differences. World J Psychiatry 2026; In press

Received	2025-12-23 10:00
Peer-Review Started	2025-12-23 10:00
First Decision by Editorial Office Director	2026-02-09 09:18
Return for Revision	2026-02-09 09:18
Revised	2026-02-23 09:16
Publication Fee Transferred	2026-02-28 10:01
Second Decision by Editor	2026-04-02 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-02 06:16
Articles in Press	2026-04-02 06:16
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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