Publication Name	World Journal of Gastroenterology
Manuscript ID	117832
Country	Germany

Category	Oncology
Manuscript Type	Observational Study
Article Title	Five-fraction stereotactic magnetic resonance-guided adaptive radiotherapy targeting the primary tumor in metastatic pancreatic cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Mohamed A Schumann, Aurélie Gaasch, Sandra Boyaci, Frederik Fuchs, Franziska Walter, Sebastian N Marschner, Chukwuka Eze, Christoph Benedikt Westphalen, Julian Walter Holch, Georg Beyer, Wolfgang G Kunz, Julia Mayerle, Maximilian Niyazi, Claus Belka, Stefanie Corradini and Paul Rogowski
Funding Agency and Grant Number
Corresponding Author	Mohamed A Schumann, Department of Radiation Oncology, LMU University Hospital, Marchioninistrasse 15, Munich 81377, Germany. mohamed.schumann@med.uni-muenchen.de
Key Words	Pancreatic cancer; Pancreatic ductal adenocarcinoma; Radiotherapy; Stereotactic body radiotherapy; Metastatic pancreatic ductal adenocarcinoma; Magnetic resonance-guided radiotherapy
Core Tip	Local progression of the primary tumor remains a major cause of morbidity in metastatic pancreatic ductal adenocarcinoma, even in the era of modern chemotherapy. This prospective observational study demonstrates that five-fraction stereotactic magnetic resonance-guided radiotherapy to the primary tumor is feasible and safe in patients with metastatic pancreatic ductal adenocarcinoma, achieving good local control, meaningful pain palliation, and low rates of high-grade toxicity. These findings support magnetic resonance-guided radiotherapy as a promising local treatment option within multimodal strategies for carefully selected patients with controlled metastatic disease.
Citation	Schumann MA, Gaasch A, Boyaci S, Fuchs F, Walter F, Marschner SN, Eze C, Westphalen CB, Holch JW, Beyer G, Kunz WG, Mayerle J, Niyazi M, Belka C, Corradini S, Rogowski P. Five-fraction stereotactic magnetic resonance-guided adaptive radiotherapy targeting the primary tumor in metastatic pancreatic cancer. World J Gastroenterol 2026; In press

Received	2025-12-18 11:55
Peer-Review Started	2025-12-18 11:55
First Decision by Editorial Office Director	2026-01-15 07:39
Return for Revision	2026-01-15 07:39
Revised	2026-01-27 15:52
Publication Fee Transferred	2026-03-05 12:45
Second Decision by Editor	2026-04-14 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-14 07:54
Articles in Press	2026-04-14 07:54
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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