Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	117841
Country	Thailand

Category	Gastroenterology & Hepatology
Manuscript Type	Prospective Study
Article Title	Distinct early gut microbiota patterns by delivery mode within 100 hours of birth
Manuscript Source	Invited Manuscript
All Author List	Palittiya Sintusek, Pavit Klomkliew, Suthida Visedthorn, Kittima Phutthawong, Tanawan Noicharoen, Areewan Soontornsook, Duc Long Tran and Sunchai Payungporn
Funding Agency and Grant Number	Funding Agency Grant Number Ratchadapiseksompotch Funds, Graduate Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand RA67/040 Thailand Science research and Innovation Fund Chulalongkorn University HEA_FF_69_225_3000_031
Corresponding Author	Palittiya Sintusek, Center of Excellence in Thai Pediatric Gastroenterology, Hepatology and Immunology, Division of Gastroenterology, Department of Pediatrics, King Chulalongkorn Memorial Hospital, Chulalongkorn University, 1873 Rama IV, Pathumwan, Bangkok 10330, Thailand. palittiya.s@chula.ac.th
Key Words	Gut microbiota; Neonate; Early life; Feeding; Normal labor; Cesarean section
Core Tip	This study characterizes the gut microbiota of healthy neonates within the first 100 hours after birth, which is a critical yet understudied window of microbial establishment. Neonates delivered by vaginal delivery showed early enrichment of Bifidobacterium, whereas those delivered by cesarean delivery exhibited a higher abundance of skin and environment-associated taxa and reduced colonization by Bifidobacterium despite predominant breastfeeding. These findings highlight the role of delivery mode as a key determinant of early microbial assembly and the need for targeted microbiota-supportive strategies for cesarean-born neonates.
Citation	Sintusek P, Klomkliew P, Visedthorn S, Phutthawong K, Noicharoen T, Soontornsook A, Tran DL, Payungporn S. Distinct early gut microbiota patterns by delivery mode within 100 hours of birth. World J Clin Pediatr 2026; In press

Received	2025-12-17 01:22
Peer-Review Started	2025-12-17 01:22
First Decision by Editorial Office Director	2026-01-08 07:49
Return for Revision	2026-01-08 07:49
Revised	2026-01-19 17:06
Publication Fee Transferred
Second Decision by Editor	2026-02-24 02:47
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-24 08:42
Articles in Press	2026-02-24 08:42
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
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