Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	117876
Country	China

Category	Oncology
Manuscript Type	Basic Study
Article Title	ASAP3 disrupts ASAP1-ARHGAP12 to inhibit RhoA and yes-associated protein/transcriptional coactivator with PDZ-binding motif, suppressing gastric cancer progression
Manuscript Source	Unsolicited Manuscript
All Author List	Xian-Bin Huang, Yuan Deng, Shi-Yi Gong, Miao Yu and Hui Cai
Funding Agency and Grant Number
Corresponding Author	Hui Cai, MD, Professor, The First Clinical Medical College of Lanzhou University, No. 1 Donggang West Road, Chengguan District, Lanzhou 730000, Gansu Province, China. caialonteam@163.com
Key Words	Gastric cancer; ASAP3; RhoA activity; ASAP1-ARHGAP12; Yes-associated protein/transcriptional coactivator with PDZ-binding motif
Core Tip	Our study identified ASAP3 as a novel tumor suppressor in gastric cancer (GC) that may suppress RhoA activity by disrupting the ASAP1-ARHGAP12 interaction, thereby activating the Hippo pathway and suppressing yes-associated protein (YAP)/transcriptional coactivator with PDZ-binding motif (TAZ)-mediated oncogenesis. These findings clarify the context-dependent function of ASAP3, uncover a new regulatory mechanism of the RhoA/YAP/TAZ axis, and provide a potential prognostic biomarker and therapeutic target for GC. Future studies will focus on validating ASAP3’s prognostic value in clinical cohorts and developing small-molecule modulators of the ASAP3 interfered ASAP1-ARHGAP12 interaction for GC therapy.
Citation	Huang XB, Deng Y, Gong SY, Yu M, Cai H. ASAP3 disrupts ASAP3 disrupts ASAP1-ARHGAP12 to inhibit RhoA and yes-associated protein/transcriptional coactivator with PDZ-binding motif, suppressing gastric cancer progression. World J Gastrointest Oncol 2026; In press

Received	2025-12-18 02:10
Peer-Review Started	2025-12-18 02:10
First Decision by Editorial Office Director	2026-02-26 07:34
Return for Revision	2026-02-27 02:31
Revised	2026-04-12 17:17
Publication Fee Transferred	2026-04-15 13:17
Second Decision by Editor	2026-05-25 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-25 07:19
Articles in Press	2026-05-25 07:19
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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