| Category |
Immunology |
| Manuscript Type |
Basic Study |
| Article Title |
Contribution of the appendix to ulcerative colitis by supplying pathogenic immunoglobulin G-producing cells
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yusuke Izutani, Takayuki Ogino, Shuhei Sakakibara, Yosuke Kishi, Yu-Chen Liu, Yusuke Nakano, Akio Fukada, Yuki Sekido, Ryuichi Kuwahara, Takako Kihara, Mitsunobu Takeda, Tsuyoshi Hata, Atsushi Hamabe, Norikatsu Miyoshi, Mamoru Uemura, Hiroki Ikeuchi, Seiichi Hirota, Kiyoshi Takeda, Tsunekazu Mizushima, Daisuke Okuzaki, Yuichiro Doki and Hidetoshi Eguchi |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Japan Society for the Promotion of Science KAKENHI |
No. 23K08192 |
| Japan Research Foundation for Clinical Pharmacology |
|
| Princess Takamatsu Cancer Research Fund |
|
| Japanese Society for Inflammatory Bowel Disease Grants-in-Aid for Inflammatory Bowel Disease Research |
|
|
| Corresponding Author |
Takayuki Ogino, MD, PhD, Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 Yamadaoka, Suita 565-0871, Japan. togino04@gesurg.med.osaka-u.ac.jp |
| Key Words |
Ulcerative colitis; Appendix; Appendectomy; Autoantibody; Immunoglobulin G |
| Core Tip |
The appendix is a potential source of pathogenic immunoglobulin G (IgG)-producing cells in patients with ulcerative colitis (UC). Appendectomy significantly reduced IgG-positive cells in the large intestine of patients with UC. Appendectomy may alleviate UC symptoms by limiting the number of pathogenic IgG-secreting cells. |
| Citation |
Izutani Y, Ogino T, Sakakibara S, Kishi Y, Liu YC, Nakano Y, Fukada A, Sekido Y, Kuwahara R, Kihara T, Takeda M, Hata T, Hamabe A, Miyoshi N, Uemura M, Ikeuchi H, Hirota S, Takeda K, Mizushima T, Okuzaki D, Doki Y, Eguchi H. Contribution of the appendix to ulcerative colitis by supplying pathogenic immunoglobulin G-producing cells. World J Gastroenterol 2026; In press |
