Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	117904
Country	Taiwan

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Gamma delta T-cell infusion plus chemotherapy induces long-term remission of gastric cancer after immunochemotherapy failure: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Yi-Hua Wu, Li-Yuan Bai, Horng-Ren Yang, Kai-Po Chang and Long-Bin Jeng
Funding Agency and Grant Number
Corresponding Author	Long-Bin Jeng, Chief, Professor, Cell Therapy Center, China Medical University Hospital, No. 2 Yude Road, North District, Taichung 404327, Taiwan. 010919@tool.caaumed.org.tw
Key Words	Gamma delta T-cell; Immune checkpoint therapy; Chemotherapy; Trifluridine/tipiracil; Ramucirumab; Antigen presentation; Prognosis; Metastatic; Advanced gastric cancer; Case report
Core Tip	Long-term survival after progression on immunochemotherapy is uncommon in metastatic gastric cancer. We report a patient with stage IV gastric adenocarcinoma who achieved radiologic and pathologic complete response after the addition of autologous gamma delta (γδ) T-cell infusions to ramucirumab and trifluridine/tipiracil. Because γδ T cells recognize stressed tumor cells independent of the major histocompatibility complex, they may retain antitumor activity even when immune checkpoint blockade fails. This case is hypothesis-generating and supports further investigation of γδ T-cell-based immunotherapy in gastric cancer.
Citation	Wu YH, Bai LY, Yang HR, Chang KP, Jeng LB. Gamma delta T-cell infusion plus chemotherapy induces long-term remission of gastric cancer after immunochemotherapy failure: A case report. World J Gastrointest Oncol 2026; In press

Received	2026-01-16 06:25
Peer-Review Started	2026-01-16 06:29
First Decision by Editorial Office Director	2026-02-03 08:20
Return for Revision	2026-02-03 08:20
Revised	2026-02-13 00:33
Publication Fee Transferred	2026-02-18 14:54
Second Decision by Editor	2026-03-11 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-11 09:42
Articles in Press	2026-03-11 09:42
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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