Publication Name	World Journal of Hepatology
Manuscript ID	117905
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Glucocorticoid therapy in acute liver failure: Survival outcomes, predictors, and a response prediction model
Manuscript Source	Unsolicited Manuscript
All Author List	Yu-Lan He, Xue-Hong Yin, Xiao-Tong Xu, Juan Li and Qing-Hua Meng
Funding Agency and Grant Number
Corresponding Author	Qing-Hua Meng, Professor, Hepatic Disease and Oncology Minimally lnvasive Interventional Center, Beijing YouAn Hospital, Capital Medical University, No. 8 Xitoutiao, Youanmen Wai, Fengtai District, Beijing 100069, China. meng_qh0805@ccmu.edu.cn
Key Words	Acute liver failure; Glucocorticoids; Prediction model; Survival; Efficacy
Core Tip	This retrospective cohort study of 179 acute liver failure patients demonstrates that glucocorticoid (GC) therapy significantly improves 28-day survival (58.3% vs 30.5%, P < 0.001). An early increase in prothrombin activity ≥ 4.5% by day 3, alongside baseline model for end-stage liver disease score < 28.5 and blood ammonia < 135.5 μg/dL, forms a highly accurate predictive model for GC response (95.2% accuracy). This model provides a practical tool to select patients most likely to benefit from GC treatment.
Citation	He YL, Yin XH, Xu XT, Juan Li, Meng QH. Glucocorticoid therapy in acute liver failure: Survival outcomes, predictors, and a response prediction model. World J Hepatol 2026; In press

Received	2025-12-22 07:54
Peer-Review Started	2025-12-22 07:54
First Decision by Editorial Office Director	2026-01-16 06:48
Return for Revision	2026-01-16 06:48
Revised	2026-01-27 14:38
Publication Fee Transferred
Second Decision by Editor	2026-03-23 02:49
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-23 06:26
Articles in Press	2026-03-23 06:26
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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