Publication Name	World Journal of Psychiatry
Manuscript ID	117965
DOI	10.5498/wjp.117965
Country	China

Category	Medicine, General & Internal
Manuscript Type	Randomized Controlled Trial
Article Title	Application of medication therapy management-based “in-hospital assessment - home-based intervention” pharmaceutical care in patients with depression
Manuscript Source	Unsolicited Manuscript
All Author List	Mei-Fang Wang, Hui-Min Zhang and Xiao-Lan Zhang
Funding Agency and Grant Number	Funding Agency Grant Number Scientific Research Project of Nantong Municipal Health Commission MSZ2024091
Corresponding Author	Xiao-Lan Zhang, Chief Pharmacist, Department of Pharmacy, Rugao Hospital of Traditional Chinese Medicine, No. 269 Dasima Road, Rucheng Town, Rugao City, Nantong 226500, Jiangsu Province, China. 3510294515@qq.com
Key Words	Medication therapy management; Depression; In-hospital assessment - home-based intervention; Medication adherence; Relapse prevention
Core Tip	To our knowledge, this is the first medication therapy management-based “in-hospital assessment - home-based intervention” model for depression care, addressing treatment discontinuity. It significantly improved 6-month adherence (71.15%) and reduced 9-month relapse to 9.62% vs conventional care. The model was associated with a 66.7% reduction in hospitalization risk, reduced direct medical costs by 38.1%, and cut adverse reactions by 25 percentage points, offering an efficient pathway for comprehensive depression management. Standardized effect sizes (Cohen’s d) for primary outcomes ranged from 0.82 to 1.24, indicating large clinical benefits.
Citation	Wang MF, Zhang HM, Zhang XL. Application of medication therapy management-based “in-hospital assessment - home-based intervention” pharmaceutical care in patients with depression. World J Psychiatry 2026; In press DOI: https://doi.org/10.5498/wjp.117965
PDF	117965-in-press.pdf

Received	2025-12-22 07:50
Peer-Review Started	2025-12-22 07:50
First Decision by Editorial Office Director	2026-02-04 07:46
Return for Revision	2026-02-04 07:46
Revised	2026-03-15 05:57
Publication Fee Transferred	2026-05-21 01:01
Second Decision by Editor	2026-07-14 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-14 07:17
Articles in Press	2026-07-14 07:17
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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