Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	117968
Country	Italy

Category	Ophthalmology
Manuscript Type	Minireviews
Article Title	Neuro-ophthalmic review on pediatric myopia: Advancing from refraction to a brain-centric model of axial growth
Manuscript Source	Invited Manuscript
All Author List	Matteo Capobianco, Simonetta Gaia Nicolosi, Edoardo Dammino, Francesco Cappellani, Marieme Khouyyi, Fabiana D’Esposito, Caterina Gagliano and Marco Zeppieri
Funding Agency and Grant Number
Corresponding Author	Marco Zeppieri, Consultant, MD, PhD, Postdoc, Department of Ophthalmology, University Hospital of Udine, p. le S. Maria della Misericordia 15, Udine 33100, Italy. mark.zeppieri@asufc.sanita.fvg.it
Key Words	Myopia; Child; Axial length; Eye; Visual pathways; Retina; Neuroplasticity; Dopamine
Core Tip	Pediatric myopia is not simply a refractive state, but a disorder of visually driven axial elongation shaped by neuroretinal signaling and developmental visual experience. Evidence supports prioritizing axial length as a core endpoint and integrating intermediate biomarkers (e.g., choroid and optical coherence tomography angiography or optical coherence tomography angiography metrics) to refine risk phenotyping and monitor response. A brain-informed “eye-brain axis” model can guide earlier prevention and individualized escalation, while avoiding overclaiming when central mechanisms remain only partially causal.
Citation	Capobianco M, Nicolosi SG, Dammino E, Cappellani F, Khouyyi M, D’Esposito F, Gagliano C, Zeppieri M. Neuro-ophthalmic review on pediatric myopia: Advancing from refraction to a brain-centric model of axial growth. World J Clin Pediatr 2026; In press

Received	2025-12-22 06:56
Peer-Review Started	2025-12-22 06:56
First Decision by Editorial Office Director	2025-12-29 09:11
Return for Revision	2025-12-29 09:11
Revised	2025-12-30 19:14
Publication Fee Transferred
Second Decision by Editor	2026-02-03 02:33
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-03 04:39
Articles in Press	2026-02-03 04:39
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com