Publication Name	World Journal of Gastroenterology
Manuscript ID	117971
Country	Spain

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Recurrence patterns and outcomes of symptomatic gallstone disease in the elderly
Manuscript Source	Unsolicited Manuscript
All Author List	Daniel Oyón, Raul Velamazán, Anna Arnau, Pablo López-Guillén, Samuel J Martínez-Domínguez, Daniel Abad Baroja, Lara M Ruiz-Belmonte, Javier Tejedor-Tejada, Raul Zapater, Noelia Martín-Vicente, Ana Belén Julián Gomara, Violeta Sastre Lozano, Juan José Manzanares García, Pablo Cañamares-Orbis, Guillermo García-Rayado, Judith Millastre Bocos, Ana Garcia Garcia de Paredes, María Vaamonde Lorenzo, Arantzazu Izagirre Arostegi, Simon Sirtl and Enrique de-Madaria
Funding Agency and Grant Number
Corresponding Author	Raul Velamazán, Department of Gastroenterology, Hospital Clínico Universitario Lozano Blesa, San Juan Bosco 15, Zaragoza 50009, Aragon, Spain. raulvs92@gmail.com
Key Words	Elderly; Gallstones; Recurrence; Biliary colic; Biliary pain; Cholangitis; Cholecystectomy; Cholecystitis; Cholelithiasis; Pancreatitis
Core Tip	Recurrence patterns after symptomatic gallstone disease in elderly patients is scarce. This multicenter study showed that patients ≥ 80 years who were managed conservatively after the index admission followed a distinct clinical course. Although the elderly patients experienced less frequent recurrences, they did experience multiple episodes more frequently that tended to occur later and be more severe. Prior endoscopic retrograde cholangiopancreatography with sphincterotomy was associated with a reduced risk of recurrence. These findings provided novel age-specific data to improve risk stratification that can tailor management strategies in this growing population.
Citation	Oyón D, Velamazán R, Arnau A, López-Guillén P, Martínez-Domínguez SJ, Abad Baroja D, Ruiz-Belmonte LM, Tejedor-Tejada J, Zapater R, Martín-Vicente N, Julián Gomara AB, Sastre Lozano V, Manzanares García JJ, Cañamares-Orbis P, García-Rayado G, Millastre Bocos J, Garcia de Paredes AG, Vaamonde Lorenzo M, Izagirre Arostegi A, Sirtl S, de-Madaria E. Recurrence patterns and outcomes of symptomatic gallstone disease in the elderly. World J Gastroenterol 2026; In press

Received	2025-12-23 10:39
Peer-Review Started	2025-12-23 10:39
First Decision by Editorial Office Director	2026-01-15 07:43
Return for Revision	2026-01-15 07:43
Revised	2026-01-27 23:37
Publication Fee Transferred	2026-01-28 19:48
Second Decision by Editor	2026-03-10 02:45
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-10 07:52
Articles in Press	2026-03-10 07:52
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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