Publication Name	World Journal of Gastroenterology
Manuscript ID	117979
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Naringenin pretreatment attenuates hepatic ischemia-reperfusion injury by activating the PI3K-Akt signaling pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Jian-Sen Lu, Hong-Liang Liang, De-Cheng Chen, Hao Pan, Tian Han, Wei-Ye Zhang, Meng Fan, Wen Hou and Zhong-Yang Shen
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Tianjin City 23JCZDJC01070 Tianjin Key Medical Discipline Construction Project TJYXZDXK-3-006A, TJYXZDXK-3-005A National Natural Science Foundation of China 82241219 National Major Scientific Research Instrument Development Project of China 82127808
Corresponding Author	Zhong-Yang Shen, Tianjin Organ Transplantation Research Center, Institute of Transplantation Medicine, Tianjin First Central Hospital, Nankai University, No. 94 Fukang Road, Nankai District, Tianjin 300071, China. zhongyangshen@nankai.edu.cn
Key Words	Hepatic ischemia-reperfusion injury; Naringenin; Phosphatidylinositol 3-kinase-protein kinase B signaling pathway; Oxidative stress; Apoptosis; Inflammatory response
Core Tip	The specific protective effects and underlying molecular mechanisms in hepatic ischemia-reperfusion injury remain to be systematically elucidated. This study demonstrates that naringenin protects the liver from ischemia-reperfusion injury by inhibiting oxidative stress, inflammatory response, and hepatocyte apoptosis, with the phosphatidylinositol 3-kinase-protein kinase B signaling pathway serving as a key regulatory axis.
Citation	Lu JS, Liang HL, Chen DC, Pan H, Han T, Zhang WY, Fan M, Hou W, Shen ZY. Naringenin pretreatment attenuates hepatic ischemia-reperfusion injury by activating the PI3K-Akt signaling pathway. World J Gastroenterol 2026; In press

Received	2025-12-22 09:07
Peer-Review Started	2025-12-22 09:07
First Decision by Editorial Office Director	2026-01-22 08:57
Return for Revision	2026-01-22 08:57
Revised	2026-02-04 10:41
Publication Fee Transferred	2026-02-05 21:37
Second Decision by Editor	2026-04-27 02:30
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-27 07:12
Articles in Press	2026-04-27 07:12
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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