Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	117983
Country	Saudi Arabia

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Non-endoscopic strategies to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis
Manuscript Source	Invited Manuscript
All Author List	Yasir M Khayyat
Funding Agency and Grant Number
Corresponding Author	Yasir M Khayyat, FACG, FACP, FRCP (C), Professor, Department of Medicine, Faculty of Medicine, Umm AL-Qura University, AlAwali District, Makkah 8156-24381, Saudi Arabia. ymkhayyat@uqu.edu.sa
Key Words	Pancreatitis; Hydration; Indomethacin, Diclofenac; Endoscopic retrograde cholangiopancreatography; Endoscopy; Post-endoscopic retrograde cholangiopancreatography pancreatitis; Non-steroidal anti-inflammatory drugs; Hydration; Prophylaxis
Core Tip	Prophylaxis for post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) should be stratified according to patient risk. Rectal non-steroidal anti-inflammatory drugs (NSAIDs) are the foundational, evidence-based intervention recommended for all patients. In high-risk individuals, the combination of rectal NSAIDs with aggressive intravenous lactated Ringer’s hydration is beneficial, particularly for reducing moderate-to-severe PEP. Prophylactic stenting of the pancreatic duct remains a key endoscopic strategy in high-risk cases. A universal, risk-adapted approach utilizing these non-endoscopic (medication and hydration) and endoscopic (stenting) measures is essential for effective prevention.
Citation	Khayyat YM. Non-endoscopic strategies to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis. World J Gastrointest Endosc 2026; In press

Received	2025-12-22 08:10
Peer-Review Started	2025-12-22 08:10
First Decision by Editorial Office Director	2026-01-08 07:55
Return for Revision	2026-01-08 07:55
Revised	2026-01-14 09:44
Publication Fee Transferred
Second Decision by Editor	2026-02-04 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-04 13:01
Articles in Press	2026-02-04 13:01
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5190 (online)
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