Publication Name	World Journal of Psychiatry
Manuscript ID	117992
Country	China

Category	Psychiatry
Manuscript Type	Retrospective Study
Article Title	Study on risk factors and interaction effects of delirium in patients with severe pneumonia in intensive care unit
Manuscript Source	Unsolicited Manuscript
All Author List	Jie Zhen, Yuan-Long Li, Yi-Fei Xu, Lin-Jia Guo and Wei Chen
Funding Agency and Grant Number	Funding Agency Grant Number 2022 Beijing Major Epidemic Prevention and Control Key Specialized Construction Project No. ZDYQFZZDZK
Corresponding Author	Wei Chen, Department of Intensive Care Unit, Beijing Shijitan Hospital, Capital Medical University, No. 10 Tieyi Road, Yangfangdian, Haidian District, Beijing 100038, China. 18101250829@163.com
Key Words	Severe pneumonia; Delirium; Risk factors; Interactions; Multi-factor dimensionality reduction
Core Tip	The results of this study show that delirium affects 25.91% of intensive care unit patients with severe pneumonia. Prolonged mechanical ventilation, elevated blood lactate levels, and higher Acute Physiology and Chronic Health Evaluation II (APACHE II) scores are independent risk factors for delirium development. Notably, diabetes, arterial oxygen saturation, and APACHE II score demonstrate significant three-way interaction effects, suggesting that delirium results from complex synergistic pathophysiological processes. Early identification of high-risk patients using these combined indicators may enable targeted preventive interventions, ultimately improving clinical outcomes in this vulnerable population.
Citation	Zhen J, Li YL, Xu YF, Guo LJ, Chen W. Study on risk factors and interaction effects of delirium in patients with severe pneumonia in intensive care unit. World J Psychiatry 2026; In press

Received	2026-02-03 09:58
Peer-Review Started	2026-02-03 09:58
First Decision by Editorial Office Director	2026-02-26 06:26
Return for Revision	2026-02-26 06:26
Revised	2026-03-12 02:26
Publication Fee Transferred
Second Decision by Editor	2026-03-23 02:46
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-23 09:33
Articles in Press	2026-03-23 09:33
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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