Publication Name	World Journal of Hepatology
Manuscript ID	117993
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Tumor necrosis factor ligand superfamily member 13B mutation-associated chronic cholangitis with cirrhosis: A case report and literature review
Manuscript Source	Unsolicited Manuscript
All Author List	Ying Zhou, Qi-Jiao Cheng, Ming-Xing Liang, Su-Qun Li, Yu-Zhi Su, Yong-Ming Cai, Zong-Qin Pan, Yu-Xin Xie, Ying-Hua Chen and Yi-Huai He
Funding Agency and Grant Number	Funding Agency Grant Number Science and Technology Planning Projects of Guizhou Province QKHJC-MS(2025)384, and QKHJC-MS(2025)392 Health Research Project of Guizhou Province gzwkj2024-103, and 2024GZWJXM0435 Scientific Research Project of the Guizhou Provincial Bureau of Traditional Chinese Medicine QZYY-2023-021 Beijing Liver and Gallbladder Mutual Aid Public Welfare Foundation Artificial Liver Special Fund iGandanF-1082024-RGG018
Corresponding Author	Yi-Huai He, MD, Department of Infectious Diseases, Affiliated Hospital of Zunyi Medical University, No. 201 Dalian Street, Zunyi 563000, Guizhou Province, China. 993565989@qq.com
Key Words	Autoimmune liver disease; Chronic cholangitis; TNFRSF13B gene; B cell homeostasis; Case report
Core Tip	Tumor necrosis factor receptor superfamily member 13B (TNFRSF13B/TACI) maintains immune homeostasis through bidirectional regulation of B cell function. This case report presents a case where a TNFRSF13B mutation that may impair TACI’s negative regulatory control over B cell activity, causing B cell hyperactivation, sustained local inflammatory responses, and chronic cholangitis progressing to cirrhosis. This finding provides a novel immunogenetic perspective for understanding certain autoimmune liver diseases of unknown etiology.
Citation	Zhou Y, Cheng QJ, Liang MX, Li SQ, Su YZ, Cai YM, Pan ZQ, Xie YX, Chen YH, He YH. Tumor necrosis factor receptor superfamily member 13B mutation-associated chronic cholangitis with cirrhosis: A case report and review of literature. World J Hepatol 2026; In press

Received	2025-12-22 08:55
Peer-Review Started	2025-12-22 08:55
First Decision by Editorial Office Director	2026-01-06 09:05
Return for Revision	2026-01-06 09:05
Revised	2026-01-19 15:17
Publication Fee Transferred	2026-01-22 02:38
Second Decision by Editor	2026-02-13 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-13 02:48
Articles in Press	2026-02-13 02:48
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com