Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	117998
Country	Viet Nam

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Subtotal colectomy with Deloyers colo-anal anastomosis for refractory ulcerative colitis: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Chuong Dinh Nguyen, Luan Minh Dang, Thuy Thi-Thanh Trinh, Huy Duc Tran, Anh The Phan, Diem Thi-Ngoc Vo, Huyen Duy-Mai Le, Thong Duy Vo and Hoang Huu Bui
Funding Agency and Grant Number
Corresponding Author	Luan Minh Dang, Lecturer, MD, Inflammatory Bowel Disease Unit, Department of Gastroenterology, University Medical Center Ho Chi Minh City, 215 Hong Bang Street, Cho Lon Ward, Ho Chi Minh City 700000, Viet Nam. luan.dm@umc.edu.vn
Key Words	Ulcerative colitis; Tofacitinib; Function-preserving subtotal colectomy; Clinical-endoscopic discordance; Differential healing; Case report
Core Tip	We report a rare case of refractory ulcerative colitis displaying “differential healing” following prolonged high-dose tofacitinib (10 mg thrice daily) rescue therapy. While the distal colon remained severely inflamed despite clinical remission (clinical-endoscopic discordance), the proximal colon achieved complete mucosal healing. This unique segmental response facilitated a function-preserving subtotal colectomy with Deloyers colo-anal anastomosis, avoiding a permanent stoma or ileal pouch. This case highlights a novel medical-surgical strategy leveraging differential healing to preserve colonic function and quality of life in complex scenarios.
Citation	Nguyen CD, Dang LM, Trinh TT, Tran HD, Phan AT, Vo DT, Le HD, Vo TD, Bui HH. Subtotal colectomy with Deloyers colo-anal anastomosis for refractory ulcerative colitis: A case report. World J Gastrointest Surg 2026; In press

Received	2025-12-22 08:28
Peer-Review Started	2025-12-22 08:28
First Decision by Editorial Office Director	2026-01-23 07:25
Return for Revision	2026-01-23 07:25
Revised	2026-01-27 05:51
Publication Fee Transferred	2026-01-28 12:23
Second Decision by Editor	2026-02-25 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-25 03:23
Articles in Press	2026-02-25 03:23
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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