Publication Name	World Journal of Transplantation
Manuscript ID	118000
Country	India

Category	Transplantation
Manuscript Type	Editorial
Article Title	Alemtuzumab or basiliximab: Rethinking induction choice beyond acute rejection in kidney transplantation
Manuscript Source	Invited Manuscript
All Author List	Pranjal Kashiv, Khushboo Saxena, Manish Ramesh Balwani, Amit Pasari and Vivek B Kute
Funding Agency and Grant Number
Corresponding Author	Vivek B Kute, Professor, Department of Nephrology, Institute of Kidney Diseases and Research Center, Dr HL Trivedi Institute of Transplantation Sciences, Civil Hospital Campus, Ahmedabad 380016, Gujarat, India. drvivekkute@rediffmail.com
Key Words	Kidney transplantation; Induction immunosuppression; Alemtuzumab; Basiliximab; Long-term graft outcomes
Core Tip	Induction immunosuppression has traditionally been judged by its ability to prevent early acute rejection, yet long-term graft outcomes are increasingly shaped by factors beyond rejection alone. Contemporary evidence suggests that profound early immune depletion may confer delayed biological costs related to immune reconstitution, viral susceptibility, malignancy, and progressive graft dysfunction. The propensity-matched analysis discussed in this editorial highlight that alemtuzumab and basiliximab achieve comparable rejection control, while diverging meaningfully in long-term outcomes. These findings underscore the need to move beyond rejection-centred metrics and adopt a proportional, individualised approach to induction selection focused on durable graft preservation and patient safety.
Citation	Kashiv P, Saxena K, Balwani MR, Pasari A, Kute VB. Alemtuzumab or basiliximab: Rethinking induction choice beyond acute rejection in kidney transplantation. World J Transplant 2026; In press

Received	2025-12-22 08:09
Peer-Review Started	2025-12-22 08:09
First Decision by Editorial Office Director	2026-01-07 06:06
Return for Revision	2026-01-07 06:06
Revised	2026-01-12 18:53
Publication Fee Transferred
Second Decision by Editor	2026-01-28 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-28 13:33
Articles in Press	2026-01-28 13:33
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3230 (online)
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