Publication Name	World Journal of Gastroenterology
Manuscript ID	118009
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Meta-Analysis
Article Title	Performance of computer-aided diagnosis for colorectal sessile serrated lesions: A systematic review and meta-analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Song Zhang, Shi-Hang Wang, You-Dong Zhao, Jia-Hui Wei, Xiang-Yu Sui, Xin Li, Huan-Wei Zhang, Zhi-Yao Huang, Cheng-Long Wang, Hao Hu, Jing Zhang, Zhao-Shen Li, Sheng-Bing Zhao and Yu Bai
Funding Agency and Grant Number	Funding Agency Grant Number China National Postdoctoral Program for Innovative Talents No. BX20230482 Shanghai Sailing Program No. 23YF1458600 Noncommunicable Chronic Diseases-National Science and Technology Major Project No. 2023ZD0501600 Shanghai Oriental Talents Program Top-Notch Project No. BJKJ2025002 Chenguang Program of Shanghai Education Development Foundation and Shanghai Municipal Education Commission No. 22CGA42 Special Clinical Research on Health Industry of Shanghai Municipal Health Commission No. 20244Y0231 Natural Science Foundation of Shanghai No. 23ZR1478700 Shanghai Eastern Talent Youth Program No. QNWS2024100 Shanghai Eastern Talent Youth Program No. QNWS2024108 Shanghai Public Health Key Discipline Project No. GWVI-11.1-21 Shanghai Medical Innovation Research Project No. 23Y11902500 Shanghai Hospital Development Center Foundation No. SHDC22025222 Changhai Hospital Special Foundation for Clinical Research Program No. 2024 LYB05 Changfeng Guhai Project of Changhai Hospital (Changying Youth Seedling Plan)
Corresponding Author	Yu Bai, Department of Gastroenterology, Changhai Hospital, Naval Medical University, No. 168 Changhai Road, Yangpu District, Shanghai 200433, China. changhaibaiyu@smmu.edu.cn
Key Words	Computer-aided diagnosis; Sessile serrated lesions; Colonoscopy; Diagnostic accuracy; Sensitivity; Specificity
Core Tip	This is the first meta-analysis to comprehensively evaluate the efficacy of computer aided diagnosis (CADx) systems in identifying sessile serrated lesions (SSLs). The meta-analysis demonstrated the limited differentiation performance of CADx systems for SSLs, which is also significantly inferior to the distinguishing ability of colonoscopists. Although CADx systems perform well in differentiating SSLs from non-SSLs with relatively high specificity, their sensitivity is far lower than that of the optical biopsy criteria, particularly for differentiating between SSL and hyperplastic polyp.
Citation	Zhang S, Wang SH, Zhao YD, Wei JH, Sui XY, Li X, Zhang HW, Huang ZY, Wang CL, Hu H, Zhang J, Li ZS, Zhao SB, Bai Y. Performance of computer-aided diagnosis for colorectal sessile serrated lesions: A systematic review and meta-analysis. World J Gastroenterol 2026; In press

Received	2025-12-22 09:11
Peer-Review Started	2025-12-22 09:11
First Decision by Editorial Office Director	2026-01-08 09:50
Return for Revision	2026-01-08 09:50
Revised	2026-01-26 16:52
Publication Fee Transferred	2026-01-27 03:33
Second Decision by Editor	2026-03-24 02:50
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-24 10:56
Articles in Press	2026-03-24 10:56
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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