Publication Name	World Journal of Cardiology
Manuscript ID	118011
Country	United States

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Meta-Analysis
Article Title	Efficacy of acetaminophen compared to ibuprofen for patent ductus arteriosus in preterm neonates: A systematic review and meta-analysis
Manuscript Source	Invited Manuscript
All Author List	Hakim Ullah Wazir, I M Khalid Reza, Maha Sajjad, Noora Inam, Tooba Fida, Noor Fatima, Aleena Sharif, Inayat Ullah, Sadaf Naz, Humaira, Muhammad Junaid Khan, Ali Dad, Hafiz Muhammad Moaaz Sajid, Usha Kumari and Salim Surani
Funding Agency and Grant Number
Corresponding Author	Salim Surani, FACP, FCCP, MD, Professor, Department of Medicine, University of Houston, 4302 University Drive, Houston, TX 77004, United States. srsurani@hotmail.com
Key Words	Patent ductus arteriosus; Acetaminophen; Ibuprofen; Preterm infants; Congenital heart disease
Core Tip	Eighteen randomized controlled trials involving 1946 patients were included. Acetaminophen demonstrates comparable efficacy to ibuprofen with a more favorable safety profile, particularly regarding gastrointestinal bleeding and renal complications. This study suggests acetaminophen as first-line pharmacologic therapy in preterm infants with contraindications to nonsteroidal anti-inflammatory drugs or increased bleeding risk/renal dysfunction.
Citation	Wazir HU, Reza IMK, Sajjad M, Inam N, Fida T, Fatima N, Sharif A, Ullah I, Naz S, Humaira, Khan MJ, Dad A, Sajid HMM, Kumari U, Surani S. Efficacy of acetaminophen compared to ibuprofen for patent ductus arteriosus in preterm neonates: A systematic review and meta-analysis. World J Cardiol 2026; In press

Received	2025-12-22 08:11
Peer-Review Started	2025-12-22 08:12
First Decision by Editorial Office Director	2025-12-31 07:57
Return for Revision	2025-12-31 07:57
Revised	2026-01-17 04:11
Publication Fee Transferred
Second Decision by Editor	2026-03-23 02:49
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-23 11:32
Articles in Press	2026-03-23 11:32
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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