Publication Name	World Journal of Psychiatry
Manuscript ID	118042
Country	China

Category	Psychiatry
Manuscript Type	Minireviews
Article Title	Bidirectional relationship between sleep disturbance and depression: Mechanisms, clinical implications, and future directions
Manuscript Source	Unsolicited Manuscript
All Author List	Muhammad Sanan, Sun Yao, Nicha Wareesawetsuwan, Pei-Fen Zhang and Xue-Qin Song
Funding Agency and Grant Number	Funding Agency Grant Number National Key Research and Development Program of China 2023YFC2506204 Henan Provincial Science and Technology Research Project 232102311069
Corresponding Author	Xue-Qin Song, MD, PhD, Professor, Department of Psychiatry, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Zhengzhou 450000, Henan Province, China. fccsongxq@zzu.edu.cn
Key Words	Depression; Sleep disturbance; Insomnia; Circadian rhythm; Cognitive behavioral therapy for insomnia
Core Tip	Sleep disturbance and depression interact in a bidirectional and self-reinforcing manner rather than a simple cause-effect relationship. Accumulating evidence shows that insomnia, poor sleep quality, and circadian rhythm disruption not only result from depression but also actively contribute to its onset, persistence, and relapse through shared neurobiological, emotional, and behavioral mechanisms. Recognizing sleep disturbance as a core and modifiable component of depressive disorders supports routine sleep assessment and the integration of targeted sleep interventions, such as cognitive behavioral therapy for insomnia, into standard depression care to improve outcomes and reduce relapse risk.
Citation	Sanan M, Yao S, Wareesawetsuwan N, Zhang PF, Song XQ. Bidirectional relationship between sleep disturbance and depression: Mechanisms, clinical implications, and future directions. World J Psychiatry 2026; In press

Received	2025-12-23 09:58
Peer-Review Started	2025-12-23 09:58
First Decision by Editorial Office Director	2026-01-27 05:54
Return for Revision	2026-01-27 05:54
Revised	2026-03-07 08:35
Publication Fee Transferred	2026-04-04 04:00
Second Decision by Editor	2026-05-18 02:49
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-18 05:38
Articles in Press	2026-05-18 05:38
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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