Publication Name	World Journal of Hepatology
Manuscript ID	118048
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Efficacy and mechanism of Xing-Pi-Qing-Gan decoction in treating alcoholic liver disease
Manuscript Source	Invited Manuscript
All Author List	Hui Gou, Ping Chen, Jin-Wei Li and Wen-Bing Wu
Funding Agency and Grant Number
Corresponding Author	Wen-Bing Wu, Lecturer, PhD, Department of Biochemistry and Molecular Biology, School of Basical Medical Sciences, Southwest Medical University, No. 1, Section 1, Xianglin Road, Longma Tan District, Luzhou 646000, Sichuan Province, China. wuwenbing5@vip.163.com
Key Words	Alcoholic liver disease; Xing-Pi-Qing-Gan decoction; DNA damage-inducible transcript 3; Nuclear factor erythroid 2-related factor 2/heme oxygenase-1 signaling pathway; Oxidative stress
Core Tip	This letter reviews Huang et al’s study on Xing-Pi-Qing-Gan decoction (XPQG) for alcoholic liver disease, demonstrating the mechanism by which XPQG inhibits liver injury by inhibiting DNA damage-inducible transcript 3 (DDIT3) and activating nuclear factor erythroid 2-related factor 2/heme oxygenase-1 through multiple sets of experiments. On the basis of affirming the scientific evidence of traditional Chinese medicine in the treatment of metabolic liver disease, this article discusses the potential regulation mechanism of the “gut-liver axis” of this prescription, and puts forward the necessity of establishing a standardized drug quality control system in the future clinical transformation.
Citation	Gou H, Chen P, Li JW, Wu WB. Efficacy and mechanism of Xing-Pi-Qing-Gan decoction in treating alcoholic liver disease. World J Hepatol 2026; In press

Received	2025-12-23 06:33
Peer-Review Started	2025-12-23 06:34
First Decision by Editorial Office Director	2026-01-07 10:22
Return for Revision	2026-01-08 00:52
Revised	2026-01-16 03:25
Publication Fee Transferred
Second Decision by Editor	2026-02-05 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-05 09:40
Articles in Press	2026-02-05 09:40
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com