| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Observational Study |
| Article Title |
Mediating roles of insulin resistance and inflammatory markers between healthy sleep scores and metabolic dysfunction-associated steatotic liver disease
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Qing-Tao Yu, Yun-Ying Lin, Zi-Hao Gui, Hua-Lin Duan, Jun-Jie Yang, Yuan Meng, Xue-Tao Peng, Lan Liu, Heng Wan and Jie Shen |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Guangdong Basic and Applied Basic Research Foundation |
2023A1515140062 |
| Guangdong-Hong Kong Technology Cooperation Funding Scheme |
2024A0505040004 |
|
| Corresponding Author |
Jie Shen, Department of Endocrinology and Metabolism, The Eighth Affiliated Hospital, Southern Medical University (The First People's Hospital of Shunde), Institute and Department of Endocrinology and Metabolism, the Eighth Affiliated Hospital, Southern Medical University (The First People's Hospital of Shunde), No.1 of Jiazi Road, Lunjiao, Shunde District, Foshan City 528308, Guangdong Province, China, Foshan 528308, Guangdong Province, China. sjiesy@smu.edu.cn |
| Key Words |
Metabolic dysfunction-associated steatotic liver disease; Healthy sleep score; Mediator; Homeostasis model assessment of insulin resistance; High-sensitivity C-reactive protein |
| Core Tip |
In a Chinese population, better sleep health, as measured by a composite healthy sleep score, is associated with a reduced prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD). This association is partially explained by mediating factors including insulin resistance, inflammation, remnant cholesterol, and non-high-density lipoprotein cholesterol. The findings highlight the improvement of overall sleep patterns as a potential public health strategy for MASLD prevention. |
| Citation |
Yu QT, Gui ZH, Lin YY, Duan HL, Yang JJ, Meng Y, Peng XT, Liu L, Wan H, Shen J. Mediating roles of insulin resistance and inflammatory markers between healthy sleep scores and metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2026; In press |
