Publication Name	World Journal of Gastroenterology
Manuscript ID	118071
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Kinetochore-associated protein 1 as a prognostic biomarker in gastric cancer: Integrative bioinformatics and experimental validation
Manuscript Source	Unsolicited Manuscript
All Author List	You-Feng Li, Chun-Yan Weng and Mi Wang
Funding Agency and Grant Number	Funding Agency Grant Number Wenzhou Applied Basic Research Program YC20250154
Corresponding Author	Mi Wang, Researcher, Department of Emergency, Wenzhou TCM Hospital of Zhejiang Chinese Medical University, No. 9 Jiaowei Road, Wenzhou 325000, Zhejiang Province, China. 605948068@qq.com
Key Words	Gastric cancer; Kinetochore-associated protein 1; Biomarker; Prognosis; The Cancer Genome Atlas
Core Tip	This study identifies kinetochore-associated protein (KNTC) 1, a key regulator of mitotic chromosome segregation, as a novel oncogenic factor in gastric cancer (GC). We demonstrated that KNTC1 was overexpressed in GC and closely associated with advanced clinicopathological features and poor prognosis. Importantly, KNTC1 expression correlated with immune cell infiltration and promoted tumor growth in vitro and in vivo. These findings highlight KNTC1 as a potential prognostic biomarker and therapeutic target for GC.
Citation	Li YF, Weng CY, Wang M. Kinetochore-associated protein 1 as a prognostic biomarker in gastric cancer: Integrative bioinformatics and experimental validation. World J Gastroenterol 2026; In press

Received	2025-12-23 11:01
Peer-Review Started	2025-12-23 11:01
First Decision by Editorial Office Director	2026-01-26 08:56
Return for Revision	2026-01-26 08:56
Revised	2026-02-06 17:44
Publication Fee Transferred	2026-02-09 02:24
Second Decision by Editor	2026-03-26 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-26 04:14
Articles in Press	2026-03-26 04:14
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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