Publication Name	World Journal of Clinical Oncology
Manuscript ID	118073
Country	China

Category	Integrative & Complementary Medicine
Manuscript Type	Minireviews
Article Title	DNA methylation in gastric precancerous lesions: Molecular mechanisms and clinical translation
Manuscript Source	Unsolicited Manuscript
All Author List	Si-Hui Zeng, Yu-Qi Wu, Wei-Jian Zhang, Yi-Tian Wang, Lin Xu and Shao-Ju Guo
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82374348
Corresponding Author	Shao-Ju Guo, Professor, Department of Spleen and Stomach Diseases, Shenzhen Hospital of Traditional Chinese Medicine, Fuhua Road, Shenzhen 518000, Guangdong Province, China. gsjgsjgsj2024@163.com
Key Words	DNA methylation; Gastric precancerous lesions; Epigenetic biomarkers; Helicobacter pylori; Intestinal metaplasia; Risk stratification; Early detection of cancer; Epigenetic therapy; Chemoprevention; Molecular mechanisms
Core Tip	DNA methylation is a pivotal epigenetic driver in gastric precarcinogenesis, orchestrating the stepwise progression from precancerous lesions to cancer. Clinically, methylation biomarkers enable non-invasive early detection, risk stratification, and prognostic assessment. Therapeutically, targeting methylation-regulating enzymes and implementing methylation-guided chemoprevention represent promising precision intervention strategies.
Citation	Zeng SH, Wu YQ, Zhang WJ, Wang YT, Xu L, Guo SJ. DNA methylation in gastric precancerous lesions: Molecular mechanisms and clinical translation. World J Clin Oncol 2026; In press

Received	2025-12-23 09:10
Peer-Review Started	2025-12-23 09:10
First Decision by Editorial Office Director	2026-01-28 09:24
Return for Revision	2026-01-29 11:17
Revised	2026-02-12 08:09
Publication Fee Transferred	2026-02-13 04:31
Second Decision by Editor	2026-03-26 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-26 07:29
Articles in Press	2026-03-26 07:29
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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