Publication Name	World Journal of Translational Medicine
Manuscript ID	118113
Country	India

Category	Cell & Tissue Engineering
Manuscript Type	Observational Study
Article Title	Phenotypic profiling and characterization of stromal vascular fraction using two Novel adipose tissue processing systems
Manuscript Source	Invited Manuscript
All Author List	Fabio Valerio Sciarretta, Vittorio Appierto, Silvana Campisi, Naveen Jeyaraman and Madhan Jeyaraman
Funding Agency and Grant Number
Corresponding Author	Madhan Jeyaraman, MD, PhD, Researcher, Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Velappanchavadi, Chennai 600077, Tamil Nadu, India. madhanjeyaraman@gmail.com
Key Words	Adipose tissue; Adipose-derived stromal cells; Mesenchymal stromal cells; Pericytes; Flow cytometry; Cartilage regeneration
Core Tip	Adipose-derived stromal cells (ADSCs) represent a heterogeneous population with mesenchymal stromal cells, pericytes, and endothelial progenitors. Subcutaneous adipose tissue provides a minimally invasive and abundant source for stromal vascular fraction isolation. A comparative analysis of untreated lipoaspirate vs Lipogems® and Body-Jet® eco systems revealed preserved viability and enhanced endothelial/pericyte proportions. Mechanical processing maintains cellular heterogeneity and niche architecture, thereby supporting the potential for safe and effective articular cartilage repair by ADSCs.
Citation	Sciarretta FV, Appierto V, Campisi S, Jeyaraman N, Jeyaraman M. Phenotypic profiling and characterization of stromal vascular fraction using two Novel adipose tissue processing systems. World J Transl Med 2026; In press

Received	2025-12-24 03:28
Peer-Review Started	2025-12-24 03:28
First Decision by Editorial Office Director	2026-01-19 08:50
Return for Revision	2026-01-19 08:50
Revised	2026-04-13 13:21
Publication Fee Transferred
Second Decision by Editor	2026-04-28 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-28 06:12
Articles in Press	2026-04-28 06:12
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6132 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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