Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	118121
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Cadherin 6 drives epithelial-mesenchymal transition and oxaliplatin resistance in gastric cancer via transforming growth factor-β/Smad signaling axis
Manuscript Source	Unsolicited Manuscript
All Author List	Zong-Xian Zhao, Qin-Lingfei Liu, Jie-Xi Fan, Shu Zhu, Fu-Sheng Wang and Zong-Ju Hu
Funding Agency and Grant Number	Funding Agency Grant Number Anhui Provincial Health Commission AHWJ2023Baa20164, AHWJ2023BBa20054
Corresponding Author	Zong-Ju Hu, Chief, PhD, Department of General Surgery, Fuyang People’s Hospital, No. 501 Sanqing Road, Yingzhou District, Fuyang 236000, Anhui Province, China. hzj130123@126.com
Key Words	Cadherin-6; Gastric cancer; Epithelial-mesenchymal transition; Transforming growth factor-beta; Oxaliplatin resistance
Core Tip	Gastric cancer (GC) is among the most prevalent and lethal malignancies globally and the molecular mechanisms of cadherin 6 (CDH6) in GC remain unclear. We verified that CDH6 is a key regulator in GC progression and oxaliplatin resistance. Mechanistically, CDH6 exerts its oncogenic effects by activating the transforming growth factor-β pathway and promoting epithelial-mesenchymal transition. Targeting the CDH6/transforming growth factor-β/Smad axis may serve as a promising therapeutic strategy to overcome oxaliplatin resistance and improve clinical outcomes in GC patients.
Citation	Zhao ZX, Liu QL, Fan JX, Zhu S, Wang FS, Hu ZJ. Cadherin 6 drives epithelial-mesenchymal transition and oxaliplatin resistance in gastric cancer via transforming growth factor-β/Smad signaling axis. World J Gastrointest Oncol 2026; In press

Received	2025-12-25 03:49
Peer-Review Started	2025-12-25 03:49
First Decision by Editorial Office Director	2026-01-07 10:25
Return for Revision	2026-01-09 07:47
Revised	2026-01-18 13:40
Publication Fee Transferred	2026-01-19 11:55
Second Decision by Editor	2026-02-25 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-25 03:48
Articles in Press	2026-02-25 03:48
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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