Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	118130
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Metabolic dysfunction–associated steatotic liver disease and obstructive sleep apnea: A cohort analysis of prevalence and hepatic outcomes
Manuscript Source	Invited Manuscript
All Author List	Rishi Chowdhary, Geng-Qing Song, Manjeet Kumar Goyal, Ashita Rukmini Vuthaluru, Kirti Arora, Rahul Chowdhary, Megh Patel, Akash Batta, Thai-Hau Koo, Venkata Sunkesula, Rohit Goyal and Omesh Goyal
Funding Agency and Grant Number
Corresponding Author	Manjeet Kumar Goyal, Department of Internal Medicine, Cleveland Clinic Akron General Hospital, Akron, Ohio, USA, 1, Akron General Avenue, AKron, Akron, OH 44308, United States. manjeetgoyal@gmail.com
Key Words	Sleep-disordered breathing; Metabolic syndrome; TriNetX; Cirrhosis; Liver fibrosis; Intermittent hypoxia; Obstructive sleep apnea; Metabolic dysfunction-associated steatotic liver disease
Core Tip	Metabolic dysfunction-associated steatotic liver disease (MASLD) and obstructive sleep apnea (OSA) often coexist due to shared risk factors. Furthermore, OSA can lead to liver complications. In this large multicenter study, patients with MASLD had a significantly higher prevalence of OSA and an earlier onset of OSA. Coexisting OSA markedly increased the long-term risk of developing hepatic fibrosis and cirrhosis. These findings highlight the importance of routine OSA screening in patients with MASLD and support integrated metabolic and sleep-focused management to prevent hepatic disease progression.
Citation	Chowdhary Ri, Song GQ, Goyal MK, Vuthaluru AR, Arora K, Chowdhary Ra, Patel M, Batta A, Koo TH, Sunkesula V, Goyal R, Goyal O. Metabolic dysfunction–associated steatotic liver disease and obstructive sleep apnea: A cohort analysis of prevalence and hepatic outcomes. World J Gastrointest Pharmacol Ther 2026; In press

Received	2025-12-24 03:42
Peer-Review Started	2025-12-24 03:43
First Decision by Editorial Office Director	2025-12-31 08:23
Return for Revision	2025-12-31 08:23
Revised	2026-01-01 17:28
Publication Fee Transferred
Second Decision by Editor	2026-02-04 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-05 03:16
Articles in Press	2026-02-05 03:16
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2150-5349 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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