Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	118132
Country	United Kingdom

Category	Endocrinology & Metabolism
Manuscript Type	Minireviews
Article Title	Incretin polyagonists as an alternative to bariatric surgery to manage obesity
Manuscript Source	Invited Manuscript
All Author List	Rohit Jacob Manoj, Cornelius J Fernandez, Sunil Nair and Joseph M Pappachan
Funding Agency and Grant Number
Corresponding Author	Joseph M Pappachan, FRCP, MD, MRCP, Professor, Senior Researcher, Faculty of Science, Manchester Metropolitan University, Oxford Road, Manchester M15 6BH, Greater Manchester, United Kingdom. drpappachan@yahoo.co.in
Key Words	Incretin polyagonists; Obesity; Bariatric surgery; Weight loss; Metabolic health; Tirzepatide; Type 2 diabetes mellitus
Core Tip	Incretins are gut hormones involved in metabolic homeostasis of human body and disorders of the incretin system is recognized as the main reason for the pathobiology of metabolic dysfunction and obesity. Incretin polyagonists are transforming the landscape of obesity treatment by offering potent, non-surgical alternatives to bariatric procedures with remarkable improvements in complications of adiposity including type 2 diabetes and metabolic dysfunction-associated fatty liver disease. Recent clinical trials demonstrate that dual and triple agonists can produce weight reductions comparable to, or in some cases approaching, those seen with bariatric surgery, while simultaneously improving glycemic control, lipid profiles, liver fat, and cardiovascular risk factors. This review discusses the current evidence base for optimal use of incretin polyagonists as an alternative to bariatric surgery.
Citation	Manoj RJ, Fernandez CJ, Nair S, Pappachan JM. Incretin polyagonists as an alternative to bariatric surgery to manage obesity. World J Gastrointest Pathophysiol 2026; In press

Received	2025-12-24 03:30
Peer-Review Started	2025-12-24 03:30
First Decision by Editorial Office Director	2026-01-07 02:38
Return for Revision	2026-01-07 02:38
Revised	2026-01-10 19:18
Publication Fee Transferred
Second Decision by Editor	2026-02-12 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-12 08:33
Articles in Press	2026-02-12 08:33
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2150-5330 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com