Publication Name	World Journal of Critical Care Medicine
Manuscript ID	118175
Country	Qatar

Category	Surgery
Manuscript Type	Meta-Analysis
Article Title	Association of early interleukin-6 level with injury severity and mortality in trauma patients: Systematic review and meta-analysis
Manuscript Source	Invited Manuscript
All Author List	Ibrahim Al-Hassani, Ayman El-Menyar, Mashhood Naduvilekandy, Ammar Al-Hassani and Hassan Al-Thani
Funding Agency and Grant Number
Corresponding Author	Ayman El-Menyar, Department of Surgery, Hamad Medical Corporation, Al-Rayyan Street, Doha 3050, Qatar. aymanco65@yahoo.com
Key Words	Serum interleukin-6; Polytrauma; Mortality; Injury severity score; Meta-analysis
Core Tip	Polytrauma is associated with increased morbidity and mortality. Use and identification of biomarkers as prognostic indicators in polytraumatized patients is therefore important. Interleukin (IL)-6 is a proinflammatory cytokine that is often elevated in polytrauma patients and is linked with worse outcomes and more severe injury. However, to date, there is only one meta-analysis published in English literature 7 years ago looking at the association between injury severity and IL-6. By integrating more recent evidence, this meta-analysis provides further support for IL-6 as a prognostic indicator not only for injury severity but also for mortality among adult polytrauma patients.
Citation	Al-Hassani I, El-Menyar A, Naduvilekandy M, Al-Hassani A, Al-Thani H. Association of early interleukin-6 level with injury severity and mortality in trauma patients: Systematic review and meta-analysis. World J Crit Care Med 2026; In press

Received	2025-12-28 14:23
Peer-Review Started	2025-12-28 14:25
First Decision by Editorial Office Director	2026-01-09 10:09
Return for Revision	2026-01-09 10:09
Revised	2026-01-14 14:28
Publication Fee Transferred
Second Decision by Editor	2026-02-06 02:48
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-06 08:13
Articles in Press	2026-02-06 08:13
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3141(online)
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