Publication Name	World Journal of Orthopedics
Manuscript ID	118182
Country	Kazakhstan

Category	Orthopedics
Manuscript Type	Basic Study
Article Title	Osteoreparative potential of composite based on nanofibrillated cellulose, xenograft, and butvar-phenolic adhesive
Manuscript Source	Unsolicited Manuscript
All Author List	Berik E Tuleubayev, Bakhtiyar K Makhatov, Vladimir A Vinokurov, Yevgeniy K Kamyshanskiy, Yekaterina Y Kossilova, Saule B Akhmetova, Amina A Koshanova, Marat Z Davletbaev and Marietta G Arutyunyan
Funding Agency and Grant Number	Funding Agency Grant Number Science Committee of the Ministry of Education and Science of the Republic of Kazakhstan АР19678427
Corresponding Author	Bakhtiyar K Makhatov, Doctorate Student, Department of Surgery Diseases, NPJSC "Karaganda Medical University", Gogol street, 40, Karaganda 100000, Kazakhstan. mahatov@qmu.kz
Key Words	Bone regeneration; Biocomposite; Nanofibrilated cellulose; Bone graft; Marburg bone bank system
Core Tip	This preclinical study investigates a tricomponent bone substitute-nanofibrillated cellulose, thermally disinfected bone xenograft (Marburg Bone Bank System), and polyvinyl butyral-phenolic (Butvar-phenolic) adhesive-implanted as a uniformly premixed composite in a rat femoral diaphyseal defect model. The mixed composite demonstrated superior cortical plate regeneration on days 30 and 60, significantly reduced intramedullary migration, and more pronounced scaffold remodeling compared with xenograft alone. In a Staphylococcus aureus-inoculated wound model, the composite markedly attenuated osteonecrosis and polymorphonuclear granulocyte infiltration. These results support its dual role as an osteoconductive/osteoinductive scaffold with inherent barrier resistance to infection-related bone injury.
Citation	Tuleubayev BE, Makhatov BK, Vinokurov VA, Kamyshanskiy YK, Kossilova YY, Akhmetova SB, Koshanova AA, Davletbaev MZ, Arutyunyan MG. Osteoreparative potential of composite based on nanofibrillated cellulose, xenograft, and butvar-phenolic adhesive. World J Orthop 2026; In press

Received	2025-12-26 02:49
Peer-Review Started	2025-12-26 02:49
First Decision by Editorial Office Director	2026-01-20 08:21
Return for Revision	2026-01-20 08:21
Revised	2026-02-06 13:34
Publication Fee Transferred	2026-02-13 11:32
Second Decision by Editor	2026-10-08 07:09
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-08 09:13
Articles in Press	2026-10-08 09:13
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-5836 (online)
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